Negative correlation between serum syndecan-1 and apolipoprotein A1 in patients with type 2 diabetes mellitus
Negative correlation between serum syndecan-1 and apolipoprotein A1 in patients with type 2 diabetes mellitus
复制标题
2型糖尿病患者血清syndecan-1与载脂蛋白A1呈负相关
DOI：
10.1007/s00592-010-0216-2
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发表时间：
2013-04
影响因子：
3.8
通讯作者：
Jing-Bo Wang,Yan-Jun Zhang,Yan Zhang,Juan Guan, Li
中科院分区：
文献类型：
--
作者：
Jing-Bo Wang,Yan-Jun Zhang,Yan Zhang,Juan Guan, Li
硫酸肝素蛋白聚糖（HSPGs）在体外参与细胞生长、凋亡和脂质代谢的调节。Syndecans是HSPGs的主要形式。Syndecan-1参与细胞生长、分化、粘附、伤口愈合和炎症的过程。此外，syndecan-1作为面向血浆腔室的正弦型跨膜HSPG，是参与脂蛋白生理的一个有希望的靶点。我们的目的是研究syndecan-1与2型糖尿病患者血脂的可能相关性。本研究采用ELISA法检测血清syndecan-1，分析syndecan-1与甘油三酯、胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、脂蛋白a、载脂蛋白（apo） B、apoA1、apoB/apoA1之间的潜在相关性。纳入41名2型糖尿病患者和31名年龄匹配的非糖尿病健康受试者（对照组）。糖尿病患者中Syndecan-1含量（26.15±2.42 ng/ml）显著高于对照组（16.85±1.98 ng/ml,t=−2.98，P= 0.005）。血清syndecan-1水平与apoA1呈负相关（r= - 0.46，P= 0.003）。多元回归分析显示，apoA1 （b= - 0.43，P= 0.003）是2型糖尿病患者血清syndecan-1水平的预测因子。
Heparan sulfate proteoglycans (HSPGs) are involved in the regulation of cell growth, apoptosis and lipid metabolism in vitro. Syndecans are the primary form of HSPGs. Syndecan-1 is involved in the processes of cell growth, differentiation, adhesion, wound healing and inflammation. Additionally, as a sinusoidal transmembrane HSPG facing the plasma compartment, syndecan-1 is a promising target to be involved in lipoprotein physiology. We aimed to examine the possible correlation of syndecan-1 and lipid profile in type 2 diabetes mellitus. In this study, serum syndecan-1 was detected by ELISA, and potential correlations between syndecan-1 and triglyceride, cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, lipoprotein a, apolipoprotein (apo) B, apoA1 and apoB/apoA1 were analyzed. Forty-one patients with type 2 diabetes and 31 age-matched, non-diabetic healthy subjects (controls) were enrolled. Syndecan-1 in patients with diabetes (26.15 ± 2.42 ng/ml) was significantly higher than that of the controls (16.85 ± 1.98 ng/ml,t= −2.98,P= 0.005). Serum syndecan-1 level correlated negatively with apoA1 (r= −0.46,P= 0.003). Multiple regression analysis showed that apoA1 (b= −0.43,P= 0.003) was a predictor of serum syndecan-1 levels in subjects with type 2 diabetes.
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DOI：
10.1001/jama.1997.03550230045035
发表时间：
1997-12
期刊：
JAMA
影响因子：
--
作者：
F. Brancati;P. Whelton;B. Randall;J. Neaton;J. Stamler;M. Klag
通讯作者：
F. Brancati;P. Whelton;B. Randall;J. Neaton;J. Stamler;M. Klag
影响因子：
8.2
作者：
K. G. Taylor;A. Wright;T. J. Carter;A. Valente;S. Betts;K. Matthews
通讯作者：
K. G. Taylor;A. Wright;T. J. Carter;A. Valente;S. Betts;K. Matthews
影响因子：
168.9
作者：
Walldius, G;Jungner, I;Steiner, E
通讯作者：
Steiner, E
影响因子：
158.5
作者：
Yang, Wenying;Lu, Juming;He, Jiang
通讯作者：
He, Jiang
DOI：
10.1007/978-3-642-70296-9_2
发表时间：
1985
期刊：
--
影响因子：
--
作者：
J. Stamler
通讯作者：
J. Stamler