Triterpenoid-Rich Extract from Antrodia camphorata Improves Physical Fatigue and Exercise Performance in Mice.
Triterpenoid-Rich Extract from Antrodia camphorata Improves Physical Fatigue and Exercise Performance in Mice.
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DOI：
10.1155/2012/364741
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Hou CC
中科院分区：
文献类型：
--
作者：
Huang CC;Hsu MC;Huang WC;Yang HR;Hou CC
Antrodia camphorata （AC）是一种生长在台湾的特有蘑菇。我们研究了AC对游泳运动和负重小鼠耐力能力的疲劳缓解作用。3组雄性癌症研究所（ICR）品系小鼠，每组10只，分别以0、50、200 mg/kg/d的剂量口服AC子实体提取物，指定载药AC-50和AC-200。趋势分析表明，AC处理增加了抓握力。AC剂量依赖性地增加游泳时间、血糖、肌肉和肝糖原水平，剂量依赖性地降低血浆乳酸和氨水平以及肌酸激酶活性。游泳耐力的增加是由于肝脏和肌肉糖原沉积的增加。樟脑可能有潜在的用途，在人体健康和抗疲劳活动。
Antrodia camphorata (AC) is an endemic mushroom that grows in Taiwan. We investigated the fatigue-alleviating effects of AC on endurance capacity in swim-exercised and weight-loading mice. Male Institute of Cancer Research (ICR) strain mice from 3 groups (n = 10 per group in each test) were orally administered AC fruiting body extract for 7 days at 0, 50, and 200 mg/kg/day, designated vehicle, AC-50, and AC-200, respectively. Trend analysis revealed that AC treatments increased grip strength. AC dose-dependently increased swim time, blood glucose, and muscular and hepatic glycogen levels and dose-dependently decreased plasma lactate and ammonia levels and creatine kinase activity. The increase in swimming endurance with AC administration was caused by an increase in liver and muscle glycogen deposition. A. camphorata may have potential for use in ergogenic and antifatigue activities.
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