Retinal blood flow in glaucomatous eyes with single-hemifield damage.
Retinal blood flow in glaucomatous eyes with single-hemifield damage.
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DOI：
10.1016/j.ophtha.2013.10.022
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发表时间：
2014-03
期刊：
影响因子：
13.7
通讯作者：
Greenfield, David S.
中科院分区：
文献类型：
--
作者：
Sehi, Mitra;Goharian, Iman;Konduru, Ranjith;Tan, Ou;Srinivas, Sowmya;Sadda, Srinivas R.;Francis, Brian A.;Huang, David;Greenfield, David S.
检查以下假设：在单半视野损伤的昏迷眼中，视网膜半球相应异常视觉半视野的视网膜血流量（RBF）显著减少;异常半视野、RBF和相应半球结构测量中视网膜敏感度（RS）降低之间存在显著相关性。前瞻性、非随机、病例对照研究。30例青光眼患者30眼视野局限于单半视野，27例对照者27眼。正常眼和青光眼眼进行了光谱域光学相干断层扫描（SDOCT）和标准自动视野检查。采用双循环扫描模式的多普勒SDOCT测量RBF。径向基函数是从记录的多普勒频移和测量的光束和血管之间的角度。计算总的和半球的RBF，视网膜神经纤维层（RNFL）和神经节细胞复合体（GCC）的值。将视网膜灵敏度值转换为1/Lambert。进行方差分析和回归分析。总和半球视网膜敏感度、RBF、RNFL和GCC值。与对照组（46.5±10.6; 0.052± 0.012mm 2）相比，青光眼患者的总RBF（34.6±12.2μL/min）和静脉横截面积（0.039± 0.009mm 2）减少（p<0.001）。与对侧半球相比，异常半球的平均RBF降低（15.3±5.4 vs 19.3±8.4μL/min，p=0.004）。与对侧半球相比，相应异常半球的RNFL和GCC较薄（87.0±20.2，103.7±20.6μm，p=0.002; 77.6±12.1和83.6±10.1μm，p=0.04）。在异常半球中，RBF与RNFL（r=0.41，p=0.02）和GCC（r=0.43，p=0.02）相关，但与视网膜敏感度（r=0.31，p=0.09）无关。与正常眼半球平均值（分别为23.2±5.3μL/min; 124.8±9.6μm; 96.1±5.7μm）相比，正常眼半球的RBF（19.3±8.4μL/min）、RNFL（103.7±20.6μ m）和GCC（83.6±10.1μm）明显降低（p<0.05）。在单半野损伤的昏迷眼中，与异常半野相关的半球的RBF显著降低。RBF减少与相应异常半球的RNFL和GCC变薄有关。减少的RBF，和RNFL和GCC损失也观察到在周边正常半球的青光眼的眼睛。
To examine the hypotheses that in glaucomatous eyes with single-hemifield damage, retinal blood flow (RBF) is significantly reduced in retinal hemisphere corresponding abnormal visual hemifield; and that there are significant associations between reduced retinal sensitivity (RS) in abnormal hemifield, RBF, and structural measurements in the corresponding hemisphere. prospective, non-randomized, case-control study. Thirty eyes of 30 glaucoma patients with visual field loss confined to a single hemifield, and 27 eyes of 27 controls. Normal and glaucomatous eyes underwent Spectral-domain optical coherence tomography (SDOCT) and standard automated perimetry. Doppler SDOCT with a double-circle scanning pattern was used to measure RBF. RBF was derived from the recorded Doppler frequency shift and the measured angle between the beam and the vessel. Total and hemispheric RBF, retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) values were calculated. The retinal sensitivity values were converted to 1/Lambert. Analysis of variance and regression analyses were performed. Total and hemispheric retinal sensitivity, RBF, RNFL and GCC values. The total RBF (34.6±12.2μL/min) and venous cross sectional area (0.039±0.009mm2) were reduced (p<0.001) in glaucoma compared with controls (46.5±10.6; 0.052±0.012mm2). Mean RBF was reduced in abnormal hemisphere compared to the opposite hemisphere (15.3±5.4 vs 19.3±8.4μL/min, p=0.004). The RNFL and GCC were thinner in the corresponding abnormal hemisphere compared with the opposite hemisphere (87.0±20.2, 103.7±20.6μm, p=0.002; 77.6±12.1 and 83.6±10.1μm, p=0.04). The RBF was correlated with RNFL (r=0.41, p=0.02) and GCC (r=0.43, p=0.02), but not the retinal sensitivity (r=0.31, p=0.09) in the abnormal hemisphere. The RBF (19.3±8.4μL/min), RNFL (103.7±20.6μm) and GCC (83.6±10.1μm) were reduced (p<0.05) in the hemisphere with apparently normal visual field in glaucomatous eyes compared with the mean hemispheric values of the normal eyes (23.2±5.3μL/min; 124.8±9.6μm; 96.1±5.7μm respectively). In glaucomatous eyes with single-hemifield damage, the RBF is significantly reduced in the hemisphere associated with the abnormal hemifield. Reduced RBF is associated with thinner RNFL and GCC in the corresponding abnormal hemisphere. Reduced RBF, and RNFL and GCC loss are also observed in the perimetrically-normal hemisphere of glaucomatous eyes.
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影响因子：
3.4
作者：
Baumann B;Potsaid B;Kraus MF;Liu JJ;Huang D;Hornegger J;Cable AE;Duker JS;Fujimoto JG
通讯作者：
Fujimoto JG
影响因子：
17.8
作者：
Kur, Joanna;Newman, Eric A.;Chan-Ling, Tailoi
通讯作者：
Chan-Ling, Tailoi
DOI：
10.3129/i08-057
发表时间：
2008-06-01
影响因子：
4.2
作者：
Lesk, Mark R.;Wajszilber, Marcelo;Deschenes, Micheline C.
通讯作者：
Deschenes, Micheline C.
DOI：
10.3129/i08-056
发表时间：
2008-06-01
影响因子：
4.2
作者：
Flammer, Josef;Mozaffarieh, Maneli
通讯作者：
Mozaffarieh, Maneli
DOI：
10.1007/978-3-642-12041-1_2
发表时间：
2011-01-01
期刊：
PEDIATRIC RETINA
影响因子：
--
作者：
Hildebrand, Goran Darius;Fielder, Alistair R.
通讯作者：
Fielder, Alistair R.