Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches.
Assessing ethanol's actions in the suprachiasmatic circadian clock using in vivo and in vitro approaches.
复制标题
使用体内和体外方法评估乙醇在视交叉上生物钟中的作用。
DOI:
10.1016/j.alcohol.2014.07.016
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发表时间:
2015
期刊:
影响因子:
--
通讯作者:
Glass,JDavid
中科院分区:
文献类型:
--
作者:
Prosser,RebeccaA;Glass,JDavid
Research over the past decade has demonstrated substantial interactions between the circadian system and the processes through which alcohol affects behavior and physiology. Here we summarize the results of our collaborative efforts focused on this intersection. Using a combination ofin vivoandin vitroapproaches, we have shown that ethanol affects many aspects of the mammalian circadian system, both acutely as well as after chronic administration. Conversely, we have shown circadian influences on ethanol consumption. Importantly, we are beginning to delve into the cellular mechanisms associated with these effects. We are also starting to form a picture of the neuroanatomical bases for many of these actions. Finally, we put our current findings into perspective by suggesting new avenues of inquiry for our future efforts.
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