Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation.
Disentangling neocortical alpha/beta and hippocampal theta/gamma oscillations in human episodic memory formation.
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DOI：
10.1016/j.neuroimage.2021.118454
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发表时间：
2021-11-15
期刊：
影响因子：
5.7
通讯作者：
Hanslmayr S
中科院分区：
文献类型：
--
作者：
Griffiths BJ;Martín-Buro MC;Staresina BP;Hanslmayr S
新皮质不同步和海马同步与记忆形成相关。新皮质 α/β 功率降低与信息感知相关。海马 theta/gamma 耦合增加与助记符结合相关。这些现象是联想记忆形成的可分离关联。为了形成情景记忆，我们必须首先处理大量有关待编码事件的感觉信息，然后将这些感觉表征绑定在一起，形成连贯的记忆轨迹。虽然这两种认知能力被认为具有两个不同的神经起源，即新皮质 α/β 振荡支持信息表示，而海马 θ-γ 相位振幅耦合支持助记符结合，但这两种神经标记之间分离的证据显然不存在。为了解决这个问题，十七名人类参与者完成了一项联想记忆任务，该任务首先涉及处理有关三个顺序呈现的刺激的信息，然后将这些刺激绑定在一起形成连贯的记忆痕迹，同时进行脑磁图记录。我们发现，在序列感知过程中，新皮质α/β功率的降低与记忆性能的增强相关，但与助记符结合无关。然而，海马 theta/gamma 相位-幅度耦合却表现出相反的模式。助记词绑定期间的增加（但不是序列感知）与增强的记忆性能相关。这些结果表明，与记忆相关的新皮质α/β功率下降和与记忆相关的海马θ/γ相位振幅耦合增加出现在记忆形成过程的不同阶段。我们推测这种时间分离反映了一种功能分离，其中新皮质α/β振荡可以支持与记忆相关的传入信息的处理，而海马θ-γ相位-幅度耦合可以支持将该信息绑定到连贯的记忆轨迹中。
Neocortical desynchrony and hippocampal synchrony correlate with memory formation. Neocortical alpha/beta power decreases correlate with information perception. Hippocampal theta/gamma coupling increases correlate with mnemonic binding. These phenomena are dissociable correlates of associative memory formation. To form an episodic memory, we must first process a vast amount of sensory information about the to-be-encoded event and then bind these sensory representations together to form a coherent memory trace. While these two cognitive capabilities are thought to have two distinct neural origins, with neocortical alpha/beta oscillations supporting information representation and hippocampal theta-gamma phase-amplitude coupling supporting mnemonic binding, evidence for a dissociation between these two neural markers is conspicuously absent. To address this, seventeen human participants completed an associative memory task that first involved processing information about three sequentially-presented stimuli, and then binding these stimuli together into a coherent memory trace, all the while undergoing MEG recordings. We found that decreases in neocortical alpha/beta power during sequence perception, but not mnemonic binding, correlated with enhanced memory performance. Hippocampal theta/gamma phase-amplitude coupling, however, showed the opposite pattern; increases during mnemonic binding (but not sequence perception) correlated with enhanced memory performance. These results demonstrate that memory-related decreases in neocortical alpha/beta power and memory-related increases in hippocampal theta/gamma phase-amplitude coupling arise at distinct stages of the memory formation process. We speculate that this temporal dissociation reflects a functional dissociation in which neocortical alpha/beta oscillations could support the processing of incoming information relevant to the memory, while hippocampal theta-gamma phase-amplitude coupling could support the binding of this information into a coherent memory trace.
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影响因子：
19.9
作者：
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通讯作者：
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DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
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DOI：
10.1073/pnas.1302351110
发表时间：
2013-08-06
影响因子：
11.1
作者：
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通讯作者：
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DOI：
10.1523/jneurosci.0640-09.2009
发表时间：
2009-10-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
Jutras MJ;Fries P;Buffalo EA
通讯作者：
Buffalo EA