Genetically distinct parallel projection populations from ventral hippocampus to prefrontal cortex
Genetically distinct parallel projection populations from ventral hippocampus to prefrontal cortex
复制标题
从腹侧海马到前额皮质的遗传上不同的平行投影群体
DOI：
10.1101/2023.02.18.529052
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Sánchez-Bellot C
中科院分区：
文献类型：
--
作者：
Sánchez-Bellot C
腹侧海马体被认为通过基因组成、下游投射或它们的组合来识别分离的神经元群体，从而发挥其多种作用。最近，我们描述了从海马腹侧到前额皮质的两个平行投影，横跨CA1的径向轴和丘下区。这两个种群具有明显的传入和传出连通性和明显的避近行为影响。在这项研究中，我们通过对每个神经元群体进行RNA测序来扩展这些数据。我们发现这两个种群有多个不同表达的基因。这些基因既与传统上认为分布在径向轴上的基因相对应，如钙结合蛋白1和pcp4，也与更多意想不到的基因相对应，包括突触后支架和GABA受体亚基。值得注意的是，在这两个人群中，许多基因的差异表达与精神疾病的发展有关，这表明这两种疾病途径的功能失衡可能是未来研究的一个有趣领域。总之，这些数据加强了通过腹侧海马径向轴向前额叶皮层投射的功能分离，并为这些角色的遗传和功能分离提供了多个目标。
The ventral hippocampus is proposed to perform its multitude of roles via segregated populations of neurons identified by either genetic makeup, downstream projection, or their combination. Recently we described two parallel projections from ventral hippocampus to prefrontal cortex, segregated across the radial axis of the CA1 and subicular areas. These two populations had distinct afferent and efferent connectivity and distinct influence of approach avoidance behaviour. In this study, we extend these data by performing RNA sequencing of each population of neurons. We find that these two populations have multiple genes that are differentially expressed. These genes correspond both to genes classically thought to be distributed across the radial axis such asCalbindin 1andPcp4, but also to more unexpected genes including postsynaptic scaffolds and GABA receptor subunits. Notably, a number of genes differentially expressed across the two populations were associated with the development of mental illness, suggesting an imbalance in the function of these two pathways in disease may be an interesting area for future research. Together, these data reinforce the dissociation of function of projections to prefrontal cortex across the radial axis of the ventral hippocampus, and provide multiple targets for both the genetic and functional dissociation of these roles.
登录
查看更多内容
影响因子：
7.7
作者：
AlSubaie R;Wee RW;Ritoux A;Mishchanchuk K;Passlack J;Regester D;MacAskill AF
通讯作者：
MacAskill AF
RGS4与中国汉族人群双相情感障碍的关联研究
影响因子：
0.9
作者：
You Li;Qian Zhao;Zhao Zhang;Pengkun Wang;R. Che;Wei Tang;G. Feng;K. Lindpaintner;Lin He;Yongyong Shi
通讯作者：
Yongyong Shi
严重精神障碍中炎症标志物的改变与合并的心脏代谢疾病危险因素无关
影响因子：
6.9
作者：
R. Mørch;I. Dieset;A. Færden;E. Reponen;S. Hope;E. Hoseth;Erlend Gardsjord;M. Aas;T. Iversen;I. Joa;G. Morken;I. Agartz;I. Melle;P. Aukrust;S. Djurovic;T. Ueland;O. Andreassen
通讯作者：
O. Andreassen
对 RGS4 作为精神疾病假定风险基因的基于基因的审查
DOI：
--
发表时间：
2018
期刊：
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
影响因子：
--
作者：
E. Schwarz
通讯作者：
E. Schwarz
影响因子：
16.2
作者：
Cembrowski, Mark S.;Bachman, Julia L.;Spruston, Nelson
通讯作者：
Spruston, Nelson