Circulating MIF Associated With Disease Severity and Clinical Response of Sublingual Immunotherapy in House Dust Mite-Induced Allergic Rhinitis.
Circulating MIF Associated With Disease Severity and Clinical Response of Sublingual Immunotherapy in House Dust Mite-Induced Allergic Rhinitis.
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循环 MIF 与屋尘螨引起的过敏性鼻炎的疾病严重程度和舌下免疫治疗的临床反应相关
DOI：
10.3389/fphar.2021.681724
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发表时间：
2021
影响因子：
5.6
通讯作者：
Gao K
中科院分区：
文献类型：
--
作者：
Xie S;Zhang H;Wang F;Xie Z;Jiang W;Gao K
背景资料：巨噬细胞移动抑制因子（MIF）被描述为参与许多炎症和过敏性疾病的促炎细胞因子，但MIF在过敏性鼻炎（AR）中的作用仍不清楚。本研究的目的是研究循环MIF水平与屋尘螨（HDM）诱导的AR之间的相关性，并评估MIF作为反映疾病严重程度和预测HDM诱导的AR患者舌下免疫治疗（SLIT）临床反应的潜在生物标志物。研究方法：在本研究中，我们纳入了160例持续性HDM诱导的AR患者（AR组），包括48例轻度AR患者（MAR组）和112例中重度AR患者（MASAR组），以及77例健康对照（HC组）。通过ELISA测定循环中MIF的水平，并评估MIF浓度与疾病严重程度之间的关系。在澳门特区组中，106名患者被分配接受SLIT 3年。在研究结束时，将患者分为反应良好组和反应不良组，并通过多变量回归分析来分析临床变量或生物标志物与临床反应之间的关联。结果：AR患者血清MIF浓度明显高于HC，尤其是MSAR患者。此外，循环MIF水平与TNSS、VAS、血清HDM特异性IgE、总IgE、血嗜酸性粒细胞计数和血嗜酸性粒细胞百分比呈正相关（均p < 0.05）。80名澳门SAR患者最终完成了SLIT，45名患者获得良好反应，35名患者导致不良反应。疗效好组血清MIF水平明显低于疗效差组（P < 0.001）。MIF的受试者工作特征分析显示预测SLIT临床反应的良好准确性（曲线下面积= 0.877，p < 0.001）。多因素回归分析显示血清MIF是影响SLIT疗效的独立因素。结论：血清MIF可作为反映AR患者病情严重程度的重要生物学指标，并可作为SLIT临床疗效的独立预测指标。
Background: Macrophage migration inhibitory factor (MIF) is described as a pro-inflammatory cytokine involved in many inflammatory and allergic disorders, but the role of MIF in allergic rhinitis (AR) remains poorly clarified. The aim of this study was to investigate the association between circulating MIF levels and house dust mite (HDM)-induced AR, and evaluate MIF as a potential biomarker in reflecting disease severity and predicting the clinical response of sublingual immunotherapy (SLIT) in HDM-induced AR patients. Methods: In this study, we enrolled 160 persistent HDM-induced AR patients (AR group), including 48 mild AR patients (MAR group) and 112 moderate–severe AR patients (MSAR group), and 77 healthy controls (HC group). Circulating levels of MIF were measured by ELISA, and the relationship between MIF concentrations and disease severity was assessed. In the MSAR group, 106 patients were assigned to receive SLIT for 3 years. At the end of the study, patients were categorized into good response group and poor response group, and associations between clinical variables or biomarkers and clinical response were analyzed by the multivariate regression analysis. Results: The concentrations of serum MIF were significantly higher in AR patients than in HCs, especially in those with MSAR. Moreover, circulating MIF levels were positively correlated with TNSS, VAS, serum HDM–specific IgE, total IgE, blood eosinophil count, and blood eosinophil percentage (all p < 0.05). Eighty MSAR patients finally completed SLIT, 45 patients obtained good response, and 35 patients resulted in poor response. The serum levels of MIF were significantly lower in the good-response group than in the poor-response group (p < 0.001). The receiver operating characteristic analysis for MIF showed good accuracy for predicting clinical response of SLIT (area under the curve = 0.877, p < 0.001). The multivariate regression analysis demonstrated that serum MIF was an independent factor for SLIT responsiveness. Conclusion: Serum MIF appeared to be an important biological indicator in reflecting disease severity and an independent predictor for clinical responsiveness of SLIT in HDM-induced AR patients.
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影响因子：
7.3
作者：
Noe JT;Mitchell RA
通讯作者：
Mitchell RA
影响因子：
2.6
作者：
Kim, Jin Youp;Rhee, Chae-Seo;Han, Doo Hee
通讯作者：
Han, Doo Hee
影响因子：
81.5
作者：
Bousquet, Jean;Anto, Josep M.;Toppila-Salmi, Sanna
通讯作者：
Toppila-Salmi, Sanna
影响因子：
1.7
作者：
Ekinci, A.
通讯作者：
Ekinci, A.
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影响因子：
2.7
作者：
Liang, Zhuoping;Yan, Bing;Zhang, Luo
通讯作者：
Zhang, Luo