Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders.
Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders.
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DOI：
10.3389/fnsys.2022.826475
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发表时间：
2022
影响因子：
3
通讯作者：
Mizumori SJY
中科院分区：
文献类型：
--
作者：
Baker PM;Mathis V;Lecourtier L;Simmons SC;Nugent FS;Hill S;Mizumori SJY
在这篇观点综述中，我们着重介绍了外侧缰核（LHb）在背景记忆、睡眠和行为灵活性中功能的一些较少探索的方面。我们提供的证据表明，LHb是很好地整合不同的内部状态和多模态的感觉信息，从记忆，压力，动机和奖励相关的电路生存和决策至关重要。我们进一步讨论了早期生活压力（ELS）对LHb功能的影响，作为一个例子，压力引起的多动症和神经调节系统内的LHb，促进快感缺乏和动机缺陷以下ELS失调。我们承认，最近的技术进步，在简化和良好控制的行为范式的神经回路的操作和记录已经在我们的理解的关键作用，LHb的动机和情绪调节，以及参与LHb功能障碍的压力引起的精神病理学是非常宝贵的。然而，我们也认为，考虑到决策的复杂方面，使用行为学相关的行为是必要的LHb的贡献在广泛的精神疾病的未来研究。我们得出结论，这个角度与一些悬而未决的问题，该领域需要考虑的多系统的方法来调查的复杂性LHb电路与环境刺激的相互作用，易患精神疾病。
In this Perspective review, we highlight some of the less explored aspects of lateral habenula (LHb) function in contextual memory, sleep, and behavioral flexibility. We provide evidence that LHb is well-situated to integrate different internal state and multimodal sensory information from memory-, stress-, motivational-, and reward-related circuits essential for both survival and decision making. We further discuss the impact of early life stress (ELS) on LHb function as an example of stress-induced hyperactivity and dysregulation of neuromodulatory systems within the LHb that promote anhedonia and motivational deficits following ELS. We acknowledge that recent technological advancements in manipulation and recording of neural circuits in simplified and well-controlled behavioral paradigms have been invaluable in our understanding of the critical role of LHb in motivation and emotional regulation as well as the involvement of LHb dysfunction in stress-induced psychopathology. However, we also argue that the use of ethologically-relevant behaviors with consideration of complex aspects of decision-making is warranted for future studies of LHb contributions in a wide range of psychiatric illnesses. We conclude this Perspective with some of the outstanding issues for the field to consider where a multi-systems approach is needed to investigate the complex nature of LHb circuitry interactions with environmental stimuli that predisposes psychiatric disorders.
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影响因子：
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作者：
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