The Role of Dextran Coatings on the Cytotoxicity Properties of Ceria Nanoparticles Toward Bone Cancer Cells
The Role of Dextran Coatings on the Cytotoxicity Properties of Ceria Nanoparticles Toward Bone Cancer Cells
复制标题
右旋糖酐涂层对二氧化铈纳米粒子对骨癌细胞的细胞毒性的作用
DOI：
10.1007/s11837-015-1336-5
复制
发表时间：
2015
期刊：
影响因子：
2.6
通讯作者：
T. Webster
中科院分区：
文献类型：
--
作者：
Hilal Yazıcı;Ece Alpaslan;T. Webster
摘要
氧化铈纳米颗粒已显示出作为纳米医学应用（尤其是癌症治疗）的抗氧化剂和辐射防护剂的巨大潜力。纳米粒子的表面化学是一个重要的特性，对其在癌症诊断、癌症治疗和细菌感染等生物应用中的性能产生重大影响。最近，已经开发出具有不同类型聚合物涂层的各种纳米氧化铈颗粒，以提高水溶性并允许针对不同应用进行表面功能化。在这项研究中，显示了涂有葡聚糖的二氧化铈纳米颗粒对骨癌细胞的细胞毒性特性的作用。具体来说，合成了 0.1 M 和 0.01 M 葡聚糖涂层的 <5 nm 二氧化铈纳米颗粒。评估了 0.1 M 和 0.01 M 葡聚糖包被的二氧化铈纳米颗粒对骨肉瘤细胞的细胞毒性。当用浓度范围为 250–1000 μg/mL 的 0.1 M 葡聚糖包被的二氧化铈纳米粒子处理骨肉瘤细胞时，观察到细胞活力的变化。相比之下，与 0.1 M 葡聚糖涂层相比，3 天后观察到 0.01 M 葡聚糖涂层对骨癌细胞的毒性最小。这些结果表明，表面葡聚糖功能化对氧化铈纳米颗粒针对骨肉瘤细胞的细胞毒性具有积极影响。
Abstract
Cerium oxide nanoparticles have demonstrated great potential as antioxidant and radioprotective agents for nanomedicine applications especially for cancer therapy. The surface chemistry of nanoparticles is an important property that has a significant effect on their performance in biological applications including cancer diagnosis, cancer treatment, and bacterial infection. Recently, various nanosized cerium oxide particles with different types of polymer coatings have been developed to improve aqueous solubility and allow for surface functionalization for distinct applications. In this study, the role of ceria nanoparticles coated with dextran on the cytotoxicity properties of bone cancer cells was shown. Specifically, 0.1 M and 0.01 M dextran-coated, <5-nm ceria nanoparticles, were synthesized. The cytotoxicity of 0.1 M and 0.01 M dextran-coated ceria nanoparticles was evaluated against osteosarcoma cells. A change in cell viability was observed when treating osteosarcoma cells with 0.1 M dextran-coated ceria nanoparticles in the 250–1000 μg/mL concentration range. In contrast, minimal toxicity to bone cancer cells was observed for the 0.01 M dextran coating after 3 days compared with the 0.1 M dextran coating. These results indicated that surface dextran functionalization had a positive impact on the cytotoxicity of cerium oxide nanoparticles against osteosarcoma cells.
影响因子：
--
作者：
Singh S;Kumar A;Karakoti A;Seal S;Self WT
通讯作者：
Self WT
影响因子：
5.4
作者：
Wason, Melissa S.;Colon, Jimmie;Das, Soumen;Seal, Sudipta;Turkson, James;Zhao, Jihe;Baker, Cheryl H.
通讯作者：
Baker, Cheryl H.
影响因子：
14
作者：
Patil, Swanand;Sandberg, Amanda;Seal, Sudipta
通讯作者：
Seal, Sudipta