Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance.
Circulating zonulin, a marker of intestinal permeability, is increased in association with obesity-associated insulin resistance.
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DOI：
10.1371/journal.pone.0037160
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Fernández-Real JM
中科院分区：
文献类型：
--
作者：
Moreno-Navarrete JM;Sabater M;Ortega F;Ricart W;Fernández-Real JM
Zonulin是唯一已知的通过调节细胞间紧密连接可逆地调节肠通透性的生理介质。为了研究肠道通透性和肥胖相关代谢紊乱之间的关系，我们的目的是研究循环zonulin根据肥胖和胰岛素抵抗。在123名高加索男性中测量了循环链蛋白（ELISA）与炎症和代谢参数（包括最小模型测量的胰岛素敏感性）的关系。血清zonulin水平随体重指数（BMI）、腰臀比（WHR）、空腹胰岛素、空腹甘油三酯、尿酸、IL-6的升高而升高，与HDL-胆固醇、胰岛素敏感性呈负相关。在多元回归分析中，在控制BMI、空腹甘油三酯和年龄的影响后，胰岛素敏感性（p = 0.002）对循环zonulin变异有独立贡献。 当将循环IL-6加入该模型时，仅BMI（p = 0.01）独立地贡献于循环zonulin方差。 总之，胰岛素敏感性和循环链蛋白之间的关系可能是通过肥胖相关的循环IL-6增加介导的。
Zonulin is the only physiological mediator known to regulate intestinal permeability reversibly by modulating intercellular tight junctions. To investigate the relationship between intestinal permeability and obesity-associated metabolic disturbances in humans, we aimed to study circulating zonulin according to obesity and insulin resistance. Circulating zonulin (ELISA) was measured in 123 caucasian men in association with inflammatory and metabolic parameters (including minimal model-measured insulin sensitivity). Circulating zonulin increased with body mass index (BMI), waist to hip ratio (WHR), fasting insulin, fasting triglycerides, uric acid and IL-6, and negatively correlated with HDL-cholesterol and insulin sensitivity. In multiple regression analysis, insulin sensitivity (p = 0.002) contributed independently to circulating zonulin variance, after controlling for the effects of BMI, fasting triglycerides and age. When circulating IL-6 was added to this model, only BMI (p = 0.01) contributed independently to circulating zonulin variance. In conclusion, the relationship between insulin sensitivity and circulating zonulin might be mediated through the obesity-related circulating IL-6 increase.
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影响因子：
64.8
作者：
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DOI：
10.1152/ajpgi.00098.2010
发表时间：
2010-08-01
影响因子：
4.5
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0906773106
发表时间：
2009-09-29
影响因子：
11.1
作者：
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通讯作者：
Fasano, Alessio