Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea.
Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea.
复制标题
DOI：
10.1111/j.1567-1364.2010.00648.x
复制
发表时间：
2010-09
影响因子：
3.2
通讯作者：
Kwon-Chung KJ
中科院分区：
文献类型：
--
作者：
Choi YH;Ngamskulrungroj P;Varma A;Sionov E;Hwang SM;Carriconde F;Meyer W;Litvintseva AP;Lee WG;Shin JH;Kim EC;Lee KW;Choi TY;Lee YS;Kwon-Chung KJ
采用PCR指纹图谱和多位点序列分型（Multilocus Sequence Typing， MLST）技术确定了新形态C /C的主要分子类型。韩国的加蒂犬种群。从1990 - 2008年诊断为隐球菌病的患者中分离的78株中，96%为新型隐球菌血清型A、交配型MATα和分子型VNI。剩下的4%是C. gatti，血清型B，交配型MATα，分子型VGIIb或VGIII。62株已知HIV病毒株中，仅有14株（22.6%）是从HIV阳性患者中分离出来的，属于分子型VNI。值得注意的是，93%的新生球菌分离物的PCR指纹图谱与VNIc基因型相同，VNIc基因型最近被确定为中国新生球菌菌株的主要基因型。与非VNIc基因型株（20%）相比，大多数VNIc基因型株（81.8%）与非hiv患者相关（p = 0.009）。与中国毒株不同的是，在韩国，大多数（60%）感染VNIc基因型毒株的非hiv患者有严重的潜在疾病，最常见的是癌症和肝病。本研究证实VNIc是从非hiv隐球菌患者分离的新生隐球菌中最普遍的基因型。
PCR fingerprinting and Multilocus Sequence Typing (MLST) was applied to determine the major molecular types of the C. neoformans/C. gattii species complex in the Republic of Korea. Of the 78 strains isolated from patients diagnosed with cryptococcosis between 1990 and 2008, 96% were C. neoformans serotype A, mating type MATα, and molecular type VNI. The remaining 4 % were C. gattii, serotype B, mating type MATα, and being either molecular type VGIIb or VGIII. Of the 62 strains with known HIV status, only 14 (22.6 %) were isolated from HIV positive patients and belonged to molecular type VNI. Remarkably, 93% of the C. neoformans isolates had identical PCR fingerprint profiles with the VNIc genotype that has recently been identified as the major genotype among C. neoformans strains in China. Most strains (81.8%) of the VNIc genotype were associated with non-HIV patients comparing to strains of the non-VNIc genotype (20%) (p = 0.009). Unlike the Chinese strains, a majority (60%) of the non-HIV patients infected with strains of the VNIc genotype in the Republic of Korea had serious underlying conditions with cancer and liver disease being the most common. This study affirms VNIc to be the most prevalent genotype of C. neoformans isolated from non-HIV patients with cryptococcosis.
登录
查看更多内容
影响因子：
5
作者：
KWONCHUNG, KJ;BENNETT, JE
通讯作者：
BENNETT, JE
影响因子：
3.3
作者：
Litvintseva, AP;Thakur, R;Mitchell, TG
通讯作者：
Mitchell, TG
影响因子：
3.1
作者：
KWONCHUNG, KJ;EDMAN, JC;WICKES, BL
通讯作者：
WICKES, BL
影响因子：
3.2
作者：
Escandon, Patricia;Sanchez, Adriana;Castaneda, Elizabeth
通讯作者：
Castaneda, Elizabeth
影响因子：
7.7
作者：
Jia, Yujiang;Sun, Jiangping;Vermund, Sten H.
通讯作者：
Vermund, Sten H.