Stomatocyte in Stomatocyte: A New Shape of Polymersome Induced via Chemical-Addition Methodology.
Stomatocyte in Stomatocyte: A New Shape of Polymersome Induced via Chemical-Addition Methodology.
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DOI：
10.1021/acs.nanolett.8b00187
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发表时间：
2018-03-14
期刊：
影响因子：
10.8
通讯作者：
Wilson DA
中科院分区：
文献类型：
--
作者：
Men Y;Li W;Janssen GJ;Rikken RSM;Wilson DA
精确控制聚合物囊泡的形状转变是一个重要而有趣的挑战，它跨越了纳米医学和纳米机器等学科。在这里，我们报告了一个快速和简便的方法，通过不平衡的聚合物自组装和形状变化的添加剂的化学添加剂的形状操纵的聚合物囊泡。由于其增加的渗透性、亲水性和融合特性，选择聚（环氧乙烷）作为添加剂，用于通过快速添加到聚合物囊泡有机溶液中使系统脱离平衡。首次获得了一种新的形状，即口胞中口胞（sto-in-sto）。此外，在不到1分钟的时间内快速变形为其他相关形状，如气孔细胞和大的复合囊泡，也得到了准确的控制在一个均匀的分散体。这种方法被证明是一个通用的策略，推动大会进一步脱离平衡，以产生不寻常的纳米结构在一个可控的和快速的方式。
Accurate control of the shape transformation of polymersome is an important and interesting challenge that spans across disciplines such as nanomedicine and nanomachine. Here, we report a fast and facile methodology of shape manipulation of polymersome via out-of-equilibrium polymer self-assembly and shape change by chemical addition of additives. Due to its increased permeability, hydrophilicity, and fusogenic properties, poly(ethylene oxide) was selected as the additive for bringing the system out of equilibrium via fast addition into the polymersome organic solution. A new shape, stomatocyte-in-stomatocyte (sto-in-sto), is obtained for the first time. Moreover, fast shape transformation within less than 1 min to other relevant shapes such as stomatocyte and large compound vesicles was also obtained and accurately controlled in a uniform dispersion. This methodology is demonstrated as a general strategy with which to push the assembly further out of equilibrium to generate unusual nanostructures in a controllable and fast manner.
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