Low-grade lymphomas. Expression of developmentally regulated B-cell antigens.
Low-grade lymphomas. Expression of developmentally regulated B-cell antigens.
复制标题
低度恶性淋巴瘤。
作者：
J. Cossman;L. Neckers;S. Hsu;D. Longo;E. Jaffe
一系列的低级别B细胞淋巴瘤进行了分析的一组免疫决定因素的流式细胞术和免疫组化。这些淋巴瘤的组织学上不同的亚类，高分化淋巴细胞（WDL），中分化淋巴细胞（IDL），和滤泡中心细胞（FCC）淋巴瘤，被发现很容易区分他们的免疫决定因素，已知在正常B细胞发育调节的表达。尽管所有病例均表达单克隆表面免疫球蛋白（sIg）、HLA-DR和抗体B1（p32）和BA 1识别的表面膜蛋白，但用其他单克隆抗体染色显示每个亚类的独特免疫表型：WDL p65（Leu 1）+，p24（BA 2）-; IDL p65+，p24+; FCC p65-，p24-。此外，荧光强度（每个细胞的决定簇数）获得的sIg，BA-1，和B1，但不是HLA-DR，是显着不同的三个淋巴瘤亚类。这三种标记物中的每一种的相对荧光强度遵循相同的模式：FCC大于IDL大于WDL。总之，这些区别特征表明，低度B细胞淋巴瘤代表了B细胞分化的停滞阶段，可能是连续的阶段。
A series of low-grade B-cell lymphomas was analyzed for a battery of immunologic determinants by flow cytometry and immunohistochemistry. Histologically distinctive subclasses of these lymphomas, well-differentiated lymphocytic (WDL), intermediately differentiated lymphocytic (IDL), and follicular center cell (FCC) lymphoma, were found to be readily distinguishable by their expression of immunologic determinants that are known to be developmentally regulated in normal B cells. Although all cases expressed monoclonal surface immunoglobulin (sIg), HLA-DR, and the surface membrane proteins recognized by antibodies B1 (p32) and BA1, staining with other monoclonal antibodies revealed unique immunologic phenotypes for each subclass: WDL p65 (Leu 1)+, p24 (BA2)-; IDL p65+, p24+; FCC p65-, p24-. Additionally, the fluorescence intensities (number of determinants per cell) obtained for sIg, BA-1, and B1, but not HLA-DR, were significantly different among the three lymphoma subclasses. The relative fluorescence intensities of each of these three markers followed the same pattern: FCC greater than IDL greater than WDL. Taken together, these distinguishing features suggest that low-grade B-cell lymphomas represent arrested, and possibly sequential, stages of B-cell differentiation.
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影响因子：
4.4
作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
通讯作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
B 细胞型滤泡性和弥漫性淋巴瘤中 T 细胞亚群的分布。
DOI：
--
发表时间：
1983
期刊：
The American journal of pathology
影响因子：
--
作者：
Harris,NL;Bhan,AK
通讯作者：
Bhan,AK
与人 B 淋巴细胞谱系细胞发生反应的单克隆抗体 (BA-1)。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Abramson,CS;Kersey,JH;LeBien,TW
通讯作者：
LeBien,TW
DOI：
10.1073/pnas.78.6.3848
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
STASHENKO, P;NADLER, LM;SCHLOSSMAN, SF
通讯作者：
SCHLOSSMAN, SF
研究单克隆抗体识别的人类 T 淋巴细胞抗原。
DOI：
10.1073/pnas.78.3.1791
发表时间：
1981
影响因子：
11.1
作者：
Engleman,EG;Warnke,R;Fox,RI;Dilley,J;Benike,CJ;Levy,R
通讯作者：
Levy,R