Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology.
Mouse Genome Database (MGD): Knowledgebase for mouse-human comparative biology.
复制标题
DOI：
10.1093/nar/gkaa1083
复制
发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Mouse Genome Database Group
中科院分区：
文献类型：
--
作者：
Blake JA;Baldarelli R;Kadin JA;Richardson JE;Smith CL;Bult CJ;Mouse Genome Database Group
小鼠基因组数据库（MGD; http://www.informatics.jax.org）是实验室小鼠的社区模式生物知识库，这是一种广泛使用的动物模型，用于人类健康和疾病的遗传和基因组基础的比较研究。MGD是与小鼠基因、基因功能、表型和人类疾病小鼠模型相关的生物学参考数据的权威来源。MGD是官方基因、等位基因和小鼠品系命名法的主要来源，基于国际标准小鼠命名法委员会制定的指南。MGD的生物定位科学家从生物医学文献和研究者直接提供的大大小小的数据集中整理信息。在本报告中，我们描述了对MGD内容和界面的重大改进，包括(i)改进了用于探索多种小鼠品系基因组的Multi Genome Viewer， （ii）包含了更多的小鼠品系和具有扩展查询选项的新小鼠品系页面，以及（iii）集成了关于小鼠品系变异的大量数据。我们还描述了文献整理流程效率的改进，以及用于研究COVID-19的小鼠模型和基因的信息门户网站的实施。
The Mouse Genome Database (MGD; http://www.informatics.jax.org) is the community model organism knowledgebase for the laboratory mouse, a widely used animal model for comparative studies of the genetic and genomic basis for human health and disease. MGD is the authoritative source for biological reference data related to mouse genes, gene functions, phenotypes and mouse models of human disease. MGD is the primary source for official gene, allele, and mouse strain nomenclature based on the guidelines set by the International Committee on Standardized Nomenclature for Mice. MGD’s biocuration scientists curate information from the biomedical literature and from large and small datasets contributed directly by investigators. In this report we describe significant enhancements to the content and interfaces at MGD, including (i) improvements in the Multi Genome Viewer for exploring the genomes of multiple mouse strains, (ii) inclusion of many more mouse strains and new mouse strain pages with extended query options and (iii) integration of extensive data about mouse strain variants. We also describe improvements to the efficiency of literature curation processes and the implementation of an information portal focused on mouse models and genes for the study of COVID-19.
登录
查看更多内容
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
影响因子：
7
作者：
Skinner, Mitchell E.;Uzilov, Andrew V.;Holmes, Ian H.
通讯作者：
Holmes, Ian H.
影响因子：
3.3
作者：
Burgess-Herbert, Sarah L.;Cox, Allison;Paigen, Beverly
通讯作者：
Paigen, Beverly
影响因子：
14.9
作者：
Smith CM;Hayamizu TF;Finger JH;Bello SM;McCright IJ;Xu J;Baldarelli RM;Beal JS;Campbell J;Corbani LE;Frost PJ;Lewis JR;Giannatto SC;Miers D;Shaw DR;Kadin JA;Richardson JE;Smith CL;Ringwald M
通讯作者：
Ringwald M
影响因子：
14.9
作者：
Bult CJ;Blake JA;Smith CL;Kadin JA;Richardson JE;Mouse Genome Database Group
通讯作者：
Mouse Genome Database Group