The mouse Gene Expression Database (GXD): 2019 update.
The mouse Gene Expression Database (GXD): 2019 update.
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DOI：
10.1093/nar/gky922
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Ringwald M
中科院分区：
文献类型：
--
作者：
Smith CM;Hayamizu TF;Finger JH;Bello SM;McCright IJ;Xu J;Baldarelli RM;Beal JS;Campbell J;Corbani LE;Frost PJ;Lewis JR;Giannatto SC;Miers D;Shaw DR;Kadin JA;Richardson JE;Smith CL;Ringwald M
小鼠基因表达数据库（GXD）是一个广泛的、精心策划的社区资源，可在www.informatics.jax.org/expression.shtml免费获得。GXD涵盖了所有发育阶段，包括野生型和突变型小鼠的RNA原位杂交、免疫组织化学、RT-PCR、northern blot和western blot实验数据。GXD的基因表达信息与小鼠基因组信息学中的其他数据集成，并与其他数据库互联，将这些数据置于更大的生物学和生物医学背景下。自上一份报告以来，通过添加新数据和实施新的web功能，GXD提供有关发育和疾病分子机制的见解的能力大大增强了。这些措施包括：对差异基因表达数据搜索的改进，促进对已被证明在特定结构和/或发育阶段只表达的基因的搜索；增强的解剖学浏览器，现在提供对给定解剖结构的表达数据和表型数据的访问；直接获取特定突变体中受影响组织的野生型基因表达数据；比较矩阵将正常表达基因的组织与基因突变导致异常的组织并置。
The mouse Gene Expression Database (GXD) is an extensive, well-curated community resource freely available at www.informatics.jax.org/expression.shtml. Covering all developmental stages, GXD includes data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot and western blot experiments in wild-type and mutant mice. GXD’s gene expression information is integrated with the other data in Mouse Genome Informatics and interconnected with other databases, placing these data in the larger biological and biomedical context. Since the last report, the ability of GXD to provide insights into the molecular mechanisms of development and disease has been greatly enhanced by the addition of new data and by the implementation of new web features. These include: improvements to the Differential Gene Expression Data Search, facilitating searches for genes that have been shown to be exclusively expressed in a specified structure and/or developmental stage; an enhanced anatomy browser that now provides access to expression data and phenotype data for a given anatomical structure; direct access to the wild-type gene expression data for the tissues affected in a specific mutant; and a comparison matrix that juxtaposes tissues where a gene is normally expressed against tissues, where mutations in that gene cause abnormalities.
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DOI：
10.1002/dvg.22864
发表时间：
2015-08
期刊：
Genesis (New York, N.Y. : 2000)
影响因子：
--
作者：
Finger JH;Smith CM;Hayamizu TF;McCright IJ;Xu J;Eppig JT;Kadin JA;Richardson JE;Ringwald M
通讯作者：
Ringwald M
影响因子：
2.5
作者：
Drabkin, Harold J.;Christie, Karen R.;Blake, Judith A.
通讯作者：
Blake, Judith A.
小鼠发育解剖学的EMAP/EMAPA本体：2013年更新。
影响因子：
1.9
作者：
Hayamizu TF;Wicks MN;Davidson DR;Burger A;Ringwald M;Baldock RA
通讯作者：
Baldock RA
影响因子：
14.9
作者：
Finger, Jacqueline H.;Smith, Constance M.;Ringwald, Martin
通讯作者：
Ringwald, Martin
影响因子：
14.9
作者：
Smith CL;Blake JA;Kadin JA;Richardson JE;Bult CJ;Mouse Genome Database Group
通讯作者：
Mouse Genome Database Group