Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies.
Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies.
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DOI：
10.3390/v4113044
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发表时间：
2012-11-12
期刊：
影响因子：
--
通讯作者：
Duval RE
中科院分区：
文献类型：
--
作者：
Geller C;Varbanov M;Duval RE
冠状病毒科（Coronaviridae）家族，包膜RNA病毒家族，并且更具体地，人冠状病毒（HCoV），历史上已知是大部分普通感冒和其他上呼吸道感染的原因。现在已知HCoV涉及更严重的呼吸道疾病，即支气管炎、细支气管炎或肺炎，特别是在幼儿和新生儿、老年人和免疫抑制患者中。它们也参与了医院内病毒感染。2002-2003年，由于新发现的冠状病毒SARS相关冠状病毒（SARS-CoV）导致严重急性呼吸道综合征（SARS）的爆发，导致对冠状病毒科的医学重要性的新认识。这种病原体是人类新出现的疾病的原因，具有致命后果的高风险;强调迫切需要新的方法来管理感染，主要是预防感染。冠状病毒的另一个有趣的特征是它们潜在的环境抵抗力，尽管包膜病毒的脆弱性是公认的。事实上，几项研究已经描述了HCoV（即HCoV 229 E，HCoV OC 43（也称为β冠状病毒1），NL 63，HKU 1或SARS-CoV）在不同环境条件下（例如温度和湿度），在医院环境中发现的不同支持物（如铝，无菌海绵或乳胶外科手套）或生物液体中存活的能力。最后，考虑到持续缺乏特异性抗病毒治疗（事实上，没有特异性治疗可用于对抗冠状病毒感染），冠状病毒科特异性（即致病性，潜在的环境抗性）使其成为开发有效预防手段的具有挑战性的模型，作为适应性的防腐-消毒，以防止此类感染因子的环境传播。本综述将总结目前关于人类冠状病毒在环境中生存能力的知识，以及已知的防腐消毒剂对它们的有效性，特别关注新方法的开发，以评估新的防腐消毒剂对病毒的活性。
The Coronaviridae family, an enveloped RNA virus family, and, more particularly, human coronaviruses (HCoV), were historically known to be responsible for a large portion of common colds and other upper respiratory tract infections. HCoV are now known to be involved in more serious respiratory diseases, i.e. bronchitis, bronchiolitis or pneumonia, especially in young children and neonates, elderly people and immunosuppressed patients. They have also been involved in nosocomial viral infections. In 2002–2003, the outbreak of severe acute respiratory syndrome (SARS), due to a newly discovered coronavirus, the SARS-associated coronavirus (SARS-CoV); led to a new awareness of the medical importance of the Coronaviridae family. This pathogen, responsible for an emerging disease in humans, with high risk of fatal outcome; underline the pressing need for new approaches to the management of the infection, and primarily to its prevention. Another interesting feature of coronaviruses is their potential environmental resistance, despite the accepted fragility of enveloped viruses. Indeed, several studies have described the ability of HCoVs (i.e. HCoV 229E, HCoV OC43 (also known as betacoronavirus 1), NL63, HKU1 or SARS-CoV) to survive in different environmental conditions (e.g. temperature and humidity), on different supports found in hospital settings such as aluminum, sterile sponges or latex surgical gloves or in biological fluids. Finally, taking into account the persisting lack of specific antiviral treatments (there is, in fact, no specific treatment available to fight coronaviruses infections), the Coronaviridae specificities (i.e. pathogenicity, potential environmental resistance) make them a challenging model for the development of efficient means of prevention, as an adapted antisepsis-disinfection, to prevent the environmental spread of such infective agents. This review will summarize current knowledge on the capacity of human coronaviruses to survive in the environment and the efficacy of well-known antiseptic-disinfectants against them, with particular focus on the development of new methodologies to evaluate the activity of new antiseptic-disinfectants on viruses.
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影响因子：
11.8
作者：
Chiu, SS;Chan, KH;Peiris, JSM
通讯作者：
Peiris, JSM
影响因子：
12.8
作者：
Casanova L;Rutala WA;Weber DJ;Sobsey MD
通讯作者：
Sobsey MD
影响因子：
5.4
作者：
Arbour, N;Côté, G;Talbot, PJ
通讯作者：
Talbot, PJ
影响因子：
12.7
作者：
Arden, KE;Nissen, MD;Mackay, IM
通讯作者：
Mackay, IM
DOI：
10.1001/jama.289.21.joc30885
发表时间：
2003-06-04
影响因子：
120.7
作者：
Booth, CM;Matukas, LM;Detsky, AS
通讯作者：
Detsky, AS