Survival of surrogate coronaviruses in water.
Survival of surrogate coronaviruses in water.
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DOI：
10.1016/j.watres.2009.02.002
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发表时间：
2009-04
期刊：
影响因子：
12.8
通讯作者：
Sobsey MD
中科院分区：
文献类型：
--
作者：
Casanova L;Rutala WA;Weber DJ;Sobsey MD
一种以前未知的冠状病毒感染--严重急性呼吸道综合征（SARS）的出现表明，粪便污染的液滴是将呼吸道病毒传播给大量人群的潜在媒介。为了评估这一途径的潜在风险，需要SARS冠状病毒的替代物来提供有关病毒在污染水中存活的代表性数据。这项研究评估了两种替代冠状病毒，传染性胃肠炎（TGEV）和小鼠肝炎（MHV）的存活率。这些病毒在水和污水中保持感染性数天至数周。在25 °C下，试剂级水减少99%所需的时间对于TGEV为22天，对于MHV为17天。在巴氏消毒的沉淀污水中，TGEV和MHV的99%减少时间分别为9天和7天。在4 °C下，四周后两种病毒的感染性降低<1 log 10。冠状病毒可以在水和巴氏消毒的沉淀污水中长时间保持传染性，这表明如果产生气溶胶，受污染的水是人类接触的潜在媒介。
The emergence of a previously unknown coronavirus infection, Severe Acute Respiratory Syndrome (SARS), demonstrated that fecally contaminated liquid droplets are a potential vehicle for the spread of a respiratory virus to large numbers of people. To assess potential risks from this pathway, there is a need for surrogates for SARS coronavirus to provide representative data on viral survival in contaminated water. This study evaluated survival of two surrogate coronaviruses, transmissible gastroenteritis (TGEV) and mouse hepatitis (MHV). These viruses remained infectious in water and sewage for days to weeks. At 25 °C, time required for 99% reduction in reagent-grade water was 22 days for TGEV and 17 days for MHV. In pasteurized settled sewage, times for 99% reduction were 9 days for TGEV and 7 days for MHV. At 4 °C, there was <1 log10 infectivity decrease for both viruses after four weeks. Coronaviruses can remain infectious for long periods in water and pasteurized settled sewage, suggesting contaminated water is a potential vehicle for human exposure if aerosols are generated.
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DOI：
10.1016/s0140-6736(03)13168-6
发表时间：
2003-05-03
期刊：
Lancet (London, England)
影响因子：
--
作者：
Seto WH;Tsang D;Yung RW;Ching TY;Ng TK;Ho M;Ho LM;Peiris JS;Advisors of Expert SARS group of Hospital Authority
通讯作者：
Advisors of Expert SARS group of Hospital Authority
影响因子：
3.1
作者：
Wang XW;Li JS;Jin M;Zhen B;Kong QX;Song N;Xiao WJ;Yin J;Wei W;Wang GJ;Si BY;Guo BZ;Liu C;Ou GR;Wang MN;Fang TY;Chao FH;Li JW
通讯作者：
Li JW
影响因子：
15.9
作者：
Liò P;Goldman N
通讯作者：
Goldman N
影响因子：
5.4
作者：
Rabenau HF;Cinatl J;Morgenstern B;Bauer G;Preiser W;Doerr HW
通讯作者：
Doerr HW
影响因子：
4.4
作者：
Noble, RT;Fuhrman, JA
通讯作者：
Fuhrman, JA