Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies.
Western-Style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies.
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西方风格的饮食，PKS岛携带大肠杆菌和大肠癌：来自两项大型前瞻性队列研究的分析。
DOI：
10.1053/j.gastro.2022.06.054
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发表时间：
2022-10
期刊：
影响因子：
29.4
通讯作者：
中科院分区：
文献类型：
--
作者：
有证据支持大肠杆菌携带编码大肠杆菌素生物合成酶的聚酮合酶（PKS）岛的致癌作用。我们假设西式饮食（富含红肉和加工肉制品）与结直肠癌发病率的关联可能在含有较高量pks+ E的肿瘤中更强。杆菌西方饮食评分是使用每四年一次的食物频率问卷数据计算的，这些数据是在两个美国国家的134,775名参与者的随访期间获得的。广泛的前瞻性队列研究。用定量聚合酶链反应测定pks+ E。在随访期间发生的3,200例结肠直肠癌病例中，有1,175例肿瘤中的大肠杆菌DNA。我们使用了3,200例病例和逆概率加权（以调整由于组织可用性而导致的选择偏倚），并整合到多变量调整的重复方法考克斯比例风险回归分析中。西方饮食评分与结直肠癌发病率的相关性在含有较高水平pks+ E的肿瘤中更强。大肠杆菌（P异质性= 0.014）。对于pks+ E，西方饮食评分的最高（与最低）三分位数的多变量校正风险比（95%置信区间）为3.45（1.53-7.78）（P趋势= 0.001）。pks+ E. pks+ E.大肠杆菌阴性肿瘤pks+ E.大肠杆菌水平与较低的疾病分期相关，但与肿瘤位置、微卫星不稳定性或BRAF、KRAS或PIK 3CA突变无关。西式饮食与结直肠癌的高发病率有关，含有丰富的pks+ E。大肠杆菌，支持饮食，肠道菌群和结直肠癌发生之间的潜在联系。我们发现，西式饮食（富含红肉、加工肉类和糖）会增加结直肠癌的风险，这些饮食中含有大量特定的产毒素大肠杆菌。大肠杆菌
Evidence supports a carcinogenic role of Escherichia coli carrying the polyketide synthase (pks) island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks+ E. coli. Western diet score was calculated using food frequency questionnaire data obtained every four years during follow-up of 134,775 participants in two U.S.-wide prospective cohort studies. Using quantitative polymerase chain reaction, we measured pks+ E. coli DNA in 1,175 tumors among 3,200 incident colorectal cancer cases that had occurred during the follow-up. We utilized the 3,200 cases and inverse probability weighting (to adjust for selection bias due to tissue availability), integrated in multivariable-adjusted duplication-method Cox proportional hazards regression analyses. The association of the western diet score with colorectal cancer incidence was stronger for tumors containing higher levels of pks+ E. coli (Pheterogeneity = 0.014). Multivariable-adjusted hazard ratios (with 95% confidence interval) for the highest (vs. lowest) tertile of the western diet score were 3.45 (1.53–7.78) (Ptrend = 0.001) for pks+ E. coli-high tumors, 1.22 (0.57–2.63) for pks+ E. coli-low tumors, and 1.10 (0.85–1.42) for pks+ E. coli-negative tumors. The pks+ E. coli level was associated with lower disease stage but not with tumor location, microsatellite instability, or BRAF, KRAS, or PIK3CA mutations. Western-style diet is associated with higher incidence of colorectal cancer containing abundant pks+ E. coli, supporting a potential link between diet, the intestinal microbiota, and colorectal carcinogenesis. We found that western-style diet (rich in red and processed meat and sugar) increased risk of colorectal cancer containing high amounts of specific toxinproducing E. coli bacterium.
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影响因子：
7.2
作者：
Berntsson, Jonna;Eberhard, Jakob;Jirstroem, Karin
通讯作者：
Jirstroem, Karin
影响因子：
5.9
作者：
Groeschel, Charlotte;Prinz-Wohlgenannt, Maximilian;Kallay, Enikoe
通讯作者：
Kallay, Enikoe
影响因子：
4.7
作者：
Abancens M;Bustos V;Harvey H;McBryan J;Harvey BJ
通讯作者：
Harvey BJ
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C
影响因子：
50.5
作者：
Gunter, M. J.;Alhomoud, S.;Chanock, S. J.
通讯作者：
Chanock, S. J.