Relation of neural response to palatable food tastes and images to future weight gain: Using bootstrap sampling to examine replicability of neuroimaging findings.
Relation of neural response to palatable food tastes and images to future weight gain: Using bootstrap sampling to examine replicability of neuroimaging findings.
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DOI：
10.1016/j.neuroimage.2018.08.035
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发表时间：
2018-12
期刊：
影响因子：
5.7
通讯作者：
Yokum S
中科院分区：
文献类型：
--
作者：
Stice E;Yokum S
因为了解预测未来体重增加的神经脆弱性因素可能会指导更有效的肥胖预防计划和治疗的设计，我们测试了对可口食物味道和图像的神经反应是否预测了未来的体重增加。我们招募了135名最初体重健康的青少年，以减少暴饮暴食史影响神经反应的可能性，让他们完成fMRI范式，检查对脂肪和糖含量不同的奶昔味道和可口食物图像的神经反应，并在3年的随访中每年评估BMI。我们使用了一种新的自举分析方法来研究功能磁共振成像结果的可重复性。全脑分析表明，补充前运动区对高脂肪/低糖奶昔味道的反应较低，预测了整个样本和10个自助样本中的5个未来BMI的增加。中央前回/Rolandic岛盖对开胃食物图像的反应升高预测了整个样本和10个自助样本中的4个未来BMI的增加。在整个样本中出现的其他峰在大多数自助样本中没有复制，这表明它们不可靠。感兴趣的区域分析没有复制在过去的论文中使用类似的范例，包括TaqIA多态性调节纹状体对可口的食物口味的反应与未来体重增加的关系的证据报告的峰值的预测效果。结果表明，较低的响应性的一个地区参与运动处理，响应可口的味道与更大的BMI随着时间的推移，并进一步自举抽样可能是有用的估计的可复制性的结果，出现从全脑分析或感兴趣的区域分析与完整的样本。
Because understanding neural vulnerability factors that predict future weight gain may guide the design of more effective obesity prevention programs and treatments, we tested whether neural response to palatable food tastes and images predicted future weight gain. We recruited 135 initially healthy weight adolescents, to reduce the possibility that a history of overeating affected neural responsivity, had them complete fMRI paradigms examining neural response to tastes of milkshakes that varied in fat and sugar content and images of palatable foods, and assessed BMI annually over a 3-year follow-up. We used a novel bootstrapping analytic approach to investigate the replicability of the fMRI findings. Whole-brain analyses indicated that lower response in the pre-supplemental motor area to high-fat/low-sugar milkshake taste predicted future BMI gain in the full sample and in 5 out of the 10 bootstrap samples. Elevated response in the precentral gyrus/Rolandic operculum to images of appetizing foods predicted future BMI gain in the full sample and in 4 out of the 10 bootstrap samples. Other peaks that emerged in the full sample did not replicate in most of the bootstrap samples, suggesting they were not reliable. Region of interest analyses did not replicate the predictive effects of peaks reported in past papers that used similar paradigms, including the evidence that TaqIA polymorphism moderated the relation of striatal response to palatable food tastes to future weight gain. Results suggest that lower responsivity of a region implicated in motor processing in response to palatable taste was associated with greater BMI gain over time, and further that bootstrap sampling may be useful for estimating the replicability of findings that emerge from whole brain analyses or regions of interest analyses with the full sample.
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