Mechanisms of murine dendritic cell antitumor dysfunction in aging.
Mechanisms of murine dendritic cell antitumor dysfunction in aging.
复制标题
衰老过程中小鼠树突状细胞抗肿瘤功能障碍的机制。
DOI：
10.1007/s00262-008-0636-9
复制
发表时间：
2009-12
影响因子：
5.8
通讯作者：
Yung, Raymond L.
中科院分区：
文献类型：
--
作者：
Grolleau-Julius, Annabelle;Abernathy, Lisa;Harning, Erin;Yung, Raymond L.
Effective cancer immunotherapy depends on the body’s ability to generate tumor antigen-presenting cells and tumor-reactive effector lymphocytes. As the most potent antigen presenting cells (APCs), dendritic cells (DCs) are capable of sensitizing T cells to new and recall antigens. Clinical trials of antigen-pulsed autologous DCs have been conducted in patients with a number of hematological and solid cancers, including malignant melanoma, lymphoma, myeloma, and non-small cell lung cancer. These studies suggest that antigen-loaded DC vaccination is a potentially safe and effective cancer therapy. However, the clinical results have been variable. Since the elderly are preferentially affected by diseases targeted by DC-directed immunotherapy, it is quite striking that few studies to date have focused on the effect of aging on DC function, a key aspect of optimal immunotherapy design in an aging population. In the present paper, we will discuss the consequences of aging on murine bone marrow-derived DC function and their use in cancer immunotherapy.
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影响因子：
64.5
作者：
Geijtenbeek, TBH;Torensma, R;Figdor, CG
通讯作者：
Figdor, CG
影响因子：
5.4
作者：
FLAMAND, V;SORNASSE, T;MOSER, M
通讯作者：
MOSER, M
DOI：
10.1093/gerona/61.10.1039
发表时间：
2006-10-01
影响因子：
5.1
作者：
Grolleau-Julius, Annabelle;Garg, Monika R.;Yung, Raymond L.
通讯作者：
Yung, Raymond L.
影响因子：
3.9
作者：
Wick, G;GrubeckLoebenstein, B
通讯作者：
GrubeckLoebenstein, B
影响因子：
15.3
作者：
Paglia, P;Chiodoni, C;Rodolfo, M;Colombo, MP
通讯作者：
Colombo, MP