Unbalance of intestinal microbiota in atopic children.
Unbalance of intestinal microbiota in atopic children.
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DOI：
10.1186/1471-2180-12-95
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发表时间：
2012-06-06
期刊：
影响因子：
4.2
通讯作者：
Brigidi P
中科院分区：
文献类型：
--
作者：
Candela M;Rampelli S;Turroni S;Severgnini M;Consolandi C;De Bellis G;Masetti R;Ricci G;Pession A;Brigidi P
肠道微生物群在宿主免疫功能中起着战略性作用，近期有人假设它与特应性疾病的病因有关。为了研究特应性疾病的胃肠道微生物生态学，我们在此对特应性儿童和健康对照的粪便微生物群进行了一项初步的比较分子分析。
招募了19名4 - 14岁的特应性儿童和12名健康对照。收集粪便，并通过已开发的系统发育微阵列平台HTF - Microbi.Array和定量PCR对粪便微生物群进行特征分析。特应性儿童的肠道微生物群显示梭菌属第IV簇、普拉梭菌、嗜黏蛋白阿克曼氏菌的数量显著减少，肠杆菌科的相对丰度相应增加。
特应性相关的微生物群中关键的免疫调节共生菌减少，可能代表一种促炎的微生物群落，这可能会加重疾病的严重程度。我们的数据为通过药用益生菌治疗特应性疾病时对肠道微生物群进行治疗性调控开辟了道路。
Playing a strategic role in the host immune function, the intestinal microbiota has been recently hypothesized to be involved in the etiology of atopy. In order to investigate the gastrointestinal microbial ecology of atopic disease, here we performed a pilot comparative molecular analysis of the faecal microbiota in atopic children and healthy controls. Nineteen atopic children and 12 healthy controls aged 4–14 years were enrolled. Stools were collected and the faecal microbiota was characterized by means of the already developed phylogenetic microarray platform, HTF-Microbi.Array, and quantitative PCR. The intestinal microbiota of atopic children showed a significant depletion in members of the Clostridium cluster IV, Faecalibacterium prausnitzii, Akkermansia muciniphila and a corresponding increase of the relative abundance of Enterobacteriaceae. Depleted in key immunomodulatory symbionts, the atopy-associated microbiota can represent an inflammogenic microbial consortium which can contribute to the severity of the disease. Our data open the way to the therapeutic manipulation of the intestinal microbiota in the treatment of atopy by means of pharmaceutical probiotics.
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DOI：
10.1126/science.1195568
发表时间：
2010-12-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Lee YK;Mazmanian SK
通讯作者：
Mazmanian SK
影响因子：
3.7
作者：
Hong PY;Lee BW;Aw M;Shek LP;Yap GC;Chua KY;Liu WT
通讯作者：
Liu WT
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
4.4
作者：
Collado, M. Carmen;Derrien, Muriel;Isolauri, Erika
通讯作者：
Isolauri, Erika
影响因子：
4.7
作者：
Consolandi, C;Severgnini, M;De Bellis, G
通讯作者：
De Bellis, G