Neuropsychological performance of South African treatment-naïve adolescents with alcohol dependence.
Neuropsychological performance of South African treatment-naïve adolescents with alcohol dependence.
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DOI：
10.1016/j.drugalcdep.2010.01.019
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发表时间：
2010-07-01
影响因子：
4.2
通讯作者：
Fein G
中科院分区：
文献类型：
--
作者：
Ferrett HL;Carey PD;Thomas KG;Tapert SF;Fein G
酒精依赖(AD)在发育脆弱的青少年中普遍存在，并有可能导致长期的神经认知后遗症，但同时存在的物质使用障碍和精神病理学可能会使解释复杂化。在这里，我们比较了患有和没有AD的青少年的认知功能，他们没有共病障碍。从南非开普敦地区招募了混血、社会经济地位较低的讲英语和南非荷兰语的青少年(13-15岁)。患有精神、发育或其他物质使用障碍(SODS)的青少年被排除在外。AD组(n=26)和对照组(n=26)在年龄、性别、语言和教育水平上匹配。在对参与者的家庭语言进行神经心理测试后，进行了详细的医学/精神病学评估。尽管我们的样本包括吸烟的参与者，但其他药物的终生剂量可以忽略不计。当烟草和其他药物的使用以及人口统计变量被控制后，患有AD的青少年在口头故事记忆、自我监控以及精神运动速度和协调性的测量上表现得更差。这些初步结果虽然相对微妙，但表明患有阿尔茨海默病的青少年无法达到最佳神经成熟水平的风险可能会增加，并且可能容易出现与长期饮酒相关的认知问题。
Alcohol dependence (AD) in developmentally vulnerable adolescents is ubiquitous and confers a risk for long-term neurocognitive sequelae, yet comorbid substance use disorders and psychopathology can complicate interpretations. Here, we compare cognitive functioning in adolescents with and without AD, who are free from comorbid disorders. English- and Afrikaans-speaking adolescents (13–15 years) of mixed ancestry and low socio-economic status were recruited from the Cape Town region of South Africa. Adolescents with psychiatric, developmental, or other substance use disorders (SUDs) were excluded. AD (n = 26) and control (n = 26) groups were matched on age, gender, language, and level of education. Neuropsychological testing in participants’ home language followed detailed medical/psychiatric evaluation. Although our sample included participants who smoked tobacco, lifetime dosage of other drugs was negligible. When tobacco and other drug use as well as demographic variables were controlled, adolescents with AD performed more poorly on measures of verbal story memory, self-monitoring, and psychomotor speed and coordination. These preliminary results, although relatively subtle, suggest that adolescents with AD may be at increased risk for failure to reach optimal levels of neuromaturation, and may be susceptible to cognitive problems associated with protracted alcohol consumption.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
2.9
作者：
Edenberg HJ;Bierut LJ;Boyce P;Cao M;Cawley S;Chiles R;Doheny KF;Hansen M;Hinrichs T;Jones K;Kelleher M;Kennedy GC;Liu G;Marcus G;McBride C;Murray SS;Oliphant A;Pettengill J;Porjesz B;Pugh EW;Rice JP;Rubano T;Shannon S;Steeke R;Tischfield JA;Tsai YY;Zhang C;Begleiter H
通讯作者：
Begleiter H
影响因子：
4.2
作者：
Di Sclafani, Victoria;Finn, Peter;Fein, George
通讯作者：
Fein, George
DOI：
10.1111/j.1530-0277.2006.00109.x
发表时间：
2006-06-01
影响因子：
3.2
作者：
Fein, George;McGillivray, Shannon;Finn, Peter
通讯作者：
Finn, Peter
影响因子：
7.6
作者：
Flisher, AJ;Parry, CDH;Lombard, C
通讯作者：
Lombard, C