Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet.
Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet.
复制标题
DOI：
10.1080/07420528.2020.1756840
复制
发表时间：
2020-06
影响因子：
2.8
通讯作者：
Seggio JA
中科院分区：
文献类型：
--
作者：
Maroni MJ;Capri KM;Arruda NL;Gelineau RR;Deane HV;Concepcion HA;DeCourcey H;Monteiro De Pina IK;Cushman AV;Chasse MH;Logan RW;Seggio JA
改变的昼夜节律对健康和行为有负面影响。新出现的证据表明，遗传影响生理和行为反应昼夜节律中断。我们研究了21小时一天（T = 21周期），高脂肪饮食消耗，自发活动，探索行为，和健康的雄性C57 BL/6 J和C57 BL/6 N小鼠的影响。将小鼠暴露于T = 24或T = 21周期，并给予标准啮齿动物食物（RC）或60%高脂肪饮食（HFD），随后进行行为测定和生理测量。我们在行为和生理测定中发现了许多品系差异，主要是与C57 BL/6 N小鼠相比，C57 BL/6 J小鼠表现出对（HFD）和焦虑样行为的致肥胖效应的易感性降低，以及昼夜节律和新奇诱导的运动活动增加。在对T = 21周期的行为反应中也存在亚群特异性差异，包括探索行为和昼夜运动活动。在21小时的一天，小鼠消耗RC显示夹带，而小鼠暴露于HFD表现出延长的活动节律。在旷场和明暗箱中，暴露于T = 21周期的小鼠具有增加的新奇诱导的运动活动，而饮食没有进一步的影响，这表明日照长度可能影响情绪相关的行为。这些结果表明，不同的昼夜节律周期影响代谢和行为反应取决于遗传背景，尽管昼夜节律夹带。
Altered circadian rhythms have negative consequences on health and behavior. Emerging evidence suggests genetics influences the physiological and behavioral responses to circadian disruption. We investigated the effects of a 21 h day (T = 21 cycle), with high-fat diet consumption, on locomotor activity, explorative behaviors, and health in male C57BL/6J and C57BL/6N mice. Mice were exposed to either a T = 24 or T = 21 cycle and given standard rodent chow (RC) or a 60% high-fat diet (HFD) followed by behavioral assays and physiological measures. We uncovered numerous strain differences within the behavioral and physiological assays, mainly that C57BL/6J mice exhibit reduced susceptibility to the obesogenic effects of (HFD) and anxiety-like behavior as well as increased circadian and novelty-induced locomotor activity compared to C57BL/6N mice. There were also substrain-specific differences in behavioral responses to the T = 21 cycle, including exploratory behaviors and circadian locomotor activity. Under the 21-h day, mice consuming RC displayed entrainment, while mice exposed to HFD exhibited a lengthening of activity rhythms. In the open-field and light-dark box, mice exposed to the T = 21 cycle had increased novelty-induced locomotor activity with no further effects of diet, suggesting daylength may affect mood-related behaviors. These results indicate that different circadian cycles impact metabolic and behavioral responses depending on genetic background, and despite circadian entrainment.
登录
查看更多内容
人脂肪外植体中时钟基因的昼夜节律。
影响因子：
6.9
作者：
Gomez-Santos, Cecilia;Gomez-Abellan, Purificacion;Madrid, Juan A.;Hernandez-Morante, Juan J.;Lujan, Juan A.;Ordovas, Jose M.;Garaulet, Marta
通讯作者：
Garaulet, Marta
影响因子：
4.2
作者：
Banks G;Heise I;Starbuck B;Osborne T;Wisby L;Potter P;Jackson IJ;Foster RG;Peirson SN;Nolan PM
通讯作者：
Nolan PM
影响因子：
29
作者：
Hatori M;Vollmers C;Zarrinpar A;DiTacchio L;Bushong EA;Gill S;Leblanc M;Chaix A;Joens M;Fitzpatrick JA;Ellisman MH;Panda S
通讯作者：
Panda S
影响因子：
3
作者：
Capri, Kimberly M.;Maroni, Marissa J.;Seggio, Joseph A.
通讯作者：
Seggio, Joseph A.
影响因子：
2.7
作者：
Fonken, Laura K.;Nelson, Randy J.
通讯作者：
Nelson, Randy J.