Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease
Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease
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动脉粥样硬化性大脑动脉疾病中的痛苦灌注和淀粉样蛋白沉积
DOI：
10.1016/j.nicl.2019.101762
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Higashi Tatsuya
中科院分区：
文献类型：
--
作者：
Yamauchi Hiroshi;Kagawa Shinya;Takahashi Masaaki;Oishi Naoya;Ono Masahiro;Higashi Tatsuya
虽然实验研究表明，在啮齿类动物中，全脑低灌流导致大脑半球淀粉样蛋白沉积并伴有颈动脉闭塞，但这种情况在人类中的结果是有争议的。因此，我们的目标是确定全球脑低灌流导致相对于代谢需求的血流量减少[氧提取分数(OEF)增加，痛苦灌流]是否与动脉粥样硬化性主要大脑动脉疾病患者大脑半球淀粉样蛋白沉积增加有关。我们用正电子发射断层扫描和[18F]-吡啶基苯并呋喃衍生物(18F-β-FYBF-2)研究了13例单侧颈内动脉硬化性疾病或大脑中动脉硬化性疾病且无皮质梗塞的患者的淀粉样斑块的分布。用动态数据和Logan图形分析计算18F-FPYBF-2的分布体积比(DVR)，并与15O-GAS PET的脑血流量(CBF)、脑氧代谢速率(CMRO2)和最大摄氧量(OEF)进行相关分析。平均皮质值计算为额叶、后扣带、楔前、顶叶和外侧颞叶皮质区的平均值。与对侧半球相比，动脉病变同侧半球CBF和CMRO2显著降低，OEF显著升高。两半球18F-FPYBF-2DVR差异无统计学意义。3例患者18F-FPYBF-2DVR的同侧/对侧比值增大，4例患者的同侧/对侧OEF比值增大。大脑半球DVR比率增加的患者(3/4)显著高于非患者(0/9)(p<； 0.02)。经多元回归分析调整对侧大脑半球18F-FYBF-2DVR后，同侧大脑半球18F-FYBF-2DVR与OEF呈正相关(p<； 0.05)，但OEF的贡献率较小(R2= 5.5%)。根据DVR值，在大脑半球OEF比率升高的4名患者中，只有1名患者显示淀粉样蛋白阳性。在动脉粥样硬化性主要大脑动脉疾病中，充其量仅伴有少量淀粉样蛋白沉积的痛苦灌注。痛苦的血流灌注与淀粉样蛋白阳性无关。
Although experimental studies have shown that global cerebral hypoperfusion leads to amyloid deposition in the hemisphere with carotid artery occlusion in rodents, the results of such occurrence are controversial in humans. Hence, we aim to determine whether global cerebral hypoperfusion leading to decreased blood flow relative to metabolic demand [increased oxygen extraction fraction (OEF), misery perfusion] is associated with increases in amyloid deposition in the hemisphere with atherosclerotic major cerebral artery disease in patients. We evaluated the distribution of β-amyloid plaques using positron emission tomography and a [18F]-pyridylbenzofuran derivative (18F-FPYBF-2) in 13 patients with unilateral atherosclerotic disease of the internal carotid artery (ICA) or middle cerebral artery (MCA) disease and no cortical infarction. The distribution volume ratio (DVR) of18F- FPYBF-2 was calculated using dynamic data and Logan graphical analysis with reference tissue and was correlated with the cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), and OEF, obtained from15O-gas PET. The mean cortical value was calculated as the mean value within the frontal, posterior cingulate, precuneus, parietal, and lateral temporal cortical regions. Significant reductions in CBF and CMRO2and increases in OEF were found in the hemisphere ipsilateral to the arterial lesion compared with the contralateral hemisphere. There was no significant difference for18F-FPYBF-2 DVR between hemispheres. The ipsilateral to contralateral ratio of the18F- FPYBF-2 DVR was increased in 3 patients, while the ipsilateral to contralateral OEF ratio was increased in 4 patients. The incidence of an increased hemispheric DVR ratio was significantly higher in patients with an increased hemispheric OEF ratio (3/4) than in patients without (0/9) (p< 0.02). Although the18F- FPYBF-2 DVR in the ipsilateral hemisphere was positively correlated with OEF after adjustment for the18F- FPYBF-2 DVR in the contralateral hemisphere using multiple regression analysis (p< 0.05), the contribution rate of OEF was small (R2= 5.5%). Only one of the 4 patients with an increased hemispheric OEF ratio showed amyloid positivity based on the DVR value. In atherosclerotic major cerebral artery disease, misery perfusion accompanied only small increases of amyloid deposition at best. Misery perfusion was not associated with amyloid positivity.
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DOI：
10.1056/nejmp1311405
发表时间：
2013-12-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Larson EB;Yaffe K;Langa KM
通讯作者：
Langa KM
影响因子：
9.3
作者：
van Berckel, Bart N. M.;Ossenkoppele, Rik;Boellaard, Ronald
通讯作者：
Boellaard, Ronald
脑低灌注大鼠模型局部脑血流及氧代谢的定量测定
影响因子：
2.9
作者：
Kato Hiroki;Kanai Yasukazu;Watabe Tadashi;Ikeda Hayato;Horitsugi Genki;Hatazawa Jun
通讯作者：
Hatazawa Jun
18F-FPYBF-2，一种新型 F-18 标记淀粉样蛋白成像 PET 示踪剂：首次人体 18F-FPYBF-2 PET 成像的生物分布和辐射剂量测定评估
影响因子：
2.6
作者：
Nishii Ryuichi;Higashi Tatsuya;Kagawa Shinya;Okuyama Chio;Kishibe Yoshihiko;Takahashi Masaaki;Okina Tomoko;Suzuki Norio;Hasegawa Hiroshi;Nagahama Yasuhiro;Ishizu Koichi;Oishi Naoya;Kimura Hiroyuki;Watanabe Hiroyuki;Ono Masahiro;Saji Hideo;Yamauchi Hiroshi
通讯作者：
Yamauchi Hiroshi
影响因子：
4.4
作者：
Huang, Kuo-Lun;Lin, Kun-Ju;Lee, Tsong-Hai
通讯作者：
Lee, Tsong-Hai