Age-Related Declines in Occipital GABA are Associated with Reduced Fluid Processing Ability.
Age-Related Declines in Occipital GABA are Associated with Reduced Fluid Processing Ability.
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DOI：
10.1016/j.acra.2018.07.024
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发表时间：
2019-08
影响因子：
4.8
通讯作者：
Polk TA
中科院分区：
文献类型：
--
作者：
Simmonite M;Carp J;Foerster BR;Ossher L;Petrou M;Weissman DH;Polk TA
健康老龄化与认知、运动和感觉功能的普遍下降有关。然而，老年人的行为表现存在着很大的个体差异。一些动物研究将与年龄相关的γ-氨基丁酸（GABA）（大脑的主要抑制性神经递质）减少与年龄相关的认知，运动和感觉下降联系起来。我们的研究使用质子磁共振波谱（MRS）在3 T，以探讨枕叶GABA是否随着年龄的增长而下降，以及枕叶GABA的个体差异是否与液体处理能力的个体差异有关。我们使用了MEGA-PRESS序列，该序列将频谱编辑与点分辨光谱序列相结合，以量化GABA。从20名年轻人（平均年龄20.7岁）和18名老年人（平均年龄76.5岁）的枕叶皮质中放置的30 × 30 × 25 mm体素获得光谱。参与者还在扫描仪外执行了11项流体处理任务，其结果被z评分并取平均值以计算流体处理能力的汇总测量值。回归分析，以确定在枕叶皮质和液体处理能力的概括措施的GABA浓度之间的关系。与年轻参与者相比，老年参与者的枕骨GABA显着降低。我们还观察到一个显着的正相关关系枕GABA和液体处理能力。事实上，较高的GABA与11项任务中的10项任务表现更好有关。这些发现表明，GABA水平随着年龄的增长而下降，并与流体处理能力的下降有关。
Healthy aging is associated with pervasive declines in cognitive, motor, and sensory functioning. There are, however, substantial individual differences in behavioral performance among older adults. Several lines of animal research link age-related reductions of gamma-aminobutyric acid (GABA), the brain’s primary inhibitory neurotransmitter, to age-related cognitive, motor, and sensory decline. Our study used proton magnetic resonance spectroscopy (MRS) at 3T to explore whether occipital GABA declines with age in humans and whether individual differences in occipital GABA are linked to individual differences in fluid processing ability. We used a MEGA-PRESS sequence that combines frequency spectral editing with a point-resolved spectroscopy sequence to quantify GABA. Spectra were obtained from a 30 × 30 × 25 mm voxel placed in the occipital cortex of 20 young adults (mean age 20.7 years) and 18 older adults (mean age 76.5 years). Participants also performed 11 fluid processing tasks outside the scanner, the results of which were z-scored and averaged to calculate a summary measure of fluid processing ability. Regression analysis was employed to determine the relationship between GABA concentrations in the occipital cortex and a summary measure of fluid processing ability. Occipital GABA was significantly lower in older participants compared to the younger participants. We also observed a significant positive relationship between occipital GABA and fluid processing ability. In fact, higher GABA was associated with better task performance in 10 of the 11 tasks. These findings suggest that GABA levels decline with age in humans and are associated with declines in fluid processing ability.
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影响因子：
3.3
作者：
Marjańska M;McCarten JR;Hodges J;Hemmy LS;Grant A;Deelchand DK;Terpstra M
通讯作者：
Terpstra M
DOI：
10.1523/jneurosci.0853-10.2010
发表时间：
2010-07-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Park J;Carp J;Hebrank A;Park DC;Polk TA
通讯作者：
Polk TA
DOI：
10.1016/j.cub.2010.09.003
发表时间：
2010-10-12
期刊：
Current biology : CB
影响因子：
--
作者：
Boy F;Evans CJ;Edden RA;Singh KD;Husain M;Sumner P
通讯作者：
Sumner P
影响因子：
5.3
作者：
Kihara, Ken;Kondo, Hirohito M.;Kawahara, Jun I.
通讯作者：
Kawahara, Jun I.
DOI：
10.1016/s0926-6410(00)00068-9
发表时间：
2001-04-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Grachev, ID;Apkarian, AV
通讯作者：
Apkarian, AV