Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using (1)H magnetic resonance spectroscopy at 7 T.
Region-specific aging of the human brain as evidenced by neurochemical profiles measured noninvasively in the posterior cingulate cortex and the occipital lobe using (1)H magnetic resonance spectroscopy at 7 T.
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DOI：
10.1016/j.neuroscience.2017.04.035
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发表时间：
2017-06-23
期刊：
影响因子：
3.3
通讯作者：
Terpstra M
中科院分区：
文献类型：
--
作者：
Marjańska M;McCarten JR;Hodges J;Hemmy LS;Grant A;Deelchand DK;Terpstra M
14个神经化学物质的浓度与代谢，神经传递，抗氧化能力和细胞结构进行了测量，非侵入性的两个不同的大脑区域，使用1H磁共振波谱。对17名年轻人（年龄19 - 22岁）和16名认知正常的老年人（年龄70 - 88岁）进行了扫描。为了提高灵敏度和特异性，在7 T的超高场和超短回波时间下获得1H磁共振谱。使用水作为内部参考并考虑感兴趣体积的灰质、白色物质和脑脊液含量来确定神经化学物质的浓度。在后扣带皮层（PCC）中，与能量相关的神经化学物质的浓度（即，肌酸加磷酸肌酸），膜周转（即，含胆碱的化合物），和神经胶质增生（即，而N-乙酰基谷氨酸（NAAG）和磷酸乙醇胺（PE）的浓度则较低。在枕叶皮质（OCC），N-乙酰天冬氨酸（NAA），神经元活力的标志物，浓度的神经递质谷氨酸和NAAG，抗氧化剂抗坏血酸（Asc），和PE的浓度较低的老年人，而含胆碱的化合物的浓度较高。总而言之，这些发现揭示了人类大脑如何根据区域而不同地老化。
The concentrations of fourteen neurochemicals associated with metabolism, neurotransmission, antioxidant capacity, and cellular structure were measured noninvasively from two distinct brain regions using 1H magnetic resonance spectroscopy. Seventeen young adults (age 19 – 22 years) and sixteen cognitively normal older adults (age 70 – 88 years) were scanned. To increase sensitivity and specificity, 1H magnetic resonance spectra were obtained at the ultra-high field of 7 T and at ultra-short echo time. The concentrations of neurochemicals were determined using water as an internal reference and accounting for gray matter, white matter, and cerebrospinal fluid content of the volume of interest. In the posterior cingulate cortex (PCC), the concentrations of neurochemicals associated with energy (i.e., creatine plus phosphocreatine), membrane turnover (i.e., choline containing compounds), and gliosis (i.e., myo-inositol) were higher in the older adults while the concentrations of N-acetylaspartylglutamate (NAAG) and phosphorylethanolamine (PE) were lower. In the occipital cortex (OCC), the concentration of N-acetylaspartate (NAA), a marker of neuronal viability, concentrations of the neurotransmitters Glu and NAAG, antioxidant ascorbate (Asc), and PE were lower in the older adults while the concentration of choline containing compounds was higher. Altogether, these findings shed light on how the human brain ages differently depending on region.
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影响因子：
2.5
作者：
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通讯作者：
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作者：
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