Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat.
Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat.
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氯沙坦对果糖诱导的高血压大鼠血压、代谢改变和血管反应性的影响。
DOI：
10.1161/01.hyp.26.6.1074
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发表时间：
1995
期刊：
影响因子：
8.3
通讯作者：
V. Lahera
中科院分区：
文献类型：
--
作者：
J. Navarro‐Cid;R. Maeso;F. Pérez;V. Cachofeiro;L. Ruilope;J. Tamargo;V. Lahera
果糖喂养诱导正常大鼠血压水平适度升高，这与胰岛素抵抗、高胰岛素血症和高胰岛素血症有关。交感神经系统似乎参与了这个模型的改变。为了进一步探讨果糖诱导的高血压的机制，研究了AT 1受体拮抗剂氯沙坦对血压、胰岛素抵抗、肾功能和肠系膜血管床血管反应性的影响。Sprague-Dawley大鼠用含60%果糖或60%淀粉（对照）的饮食喂养4周，每组一半的大鼠在饮用水中接受氯沙坦（1 mg/kg/天）。与对照组相比，果糖喂养的大鼠显示出更高（P <0.05）的血压水平和甘油三酯和胰岛素的血浆浓度。氯沙坦治疗可预防果糖喂养大鼠的血压升高和高胰岛素血症，但不能预防血浆甘油三酯升高。口服葡萄糖负荷后，果糖喂养大鼠的血糖和胰岛素水平高于对照组（P <0.05）。氯沙坦治疗可预防这些过度反应。两组间肠系膜血管床对KCl（60 μ mol）、血管紧张素II（1 nmol）、苯肾上腺素（10（-5）mol/L）或内皮素-1（10 pmol）的收缩反应无差异。两组对乙酰胆碱或硝普钠在苯肾上腺素预收缩的肠系膜血管床的舒张反应和对一氧化氮合成抑制剂NG-硝基-L-精氨酸甲酯（100 nmol）的收缩反应相当。在所有组中，氯沙坦减弱血管紧张素II收缩并降低（P <0.05）对苯肾上腺素的反应。（250字处删节）
Fructose feeding induces a moderate increase in blood pressure levels in normal rats that is associated with insulin resistance, hyperinsulinemia, and hypertriglyceridemia. The sympathetic nervous system seems to participate in the alterations of this model. To further explore the mechanisms underlying fructose-induced hypertension, the effects of the AT1 receptor antagonist losartan on blood pressure, insulin resistance, renal function, and vascular reactivity in mesenteric vascular beds were studied. Sprague-Dawley rats were fed for 4 weeks with diets containing 60% fructose or 60% starch (control), and half of each group received losartan (1 mg/kg per day) in the drinking water. Fructose-fed rats showed higher (P < .05) blood pressure levels and plasma concentrations of triglycerides and insulin than those of controls. Losartan treatment prevented both blood pressure elevation and hyperinsulinemia in fructose-fed rats but not elevation of plasma triglycerides. Plasma glucose and insulin levels in response to an oral glucose load were higher (P < .05) in fructose-fed rats than in controls. These exaggerated responses were prevented by losartan treatment. No differences in the constrictor responses of mesenteric vascular beds to KCl (60 mumol), angiotensin II (1 nmol), phenylephrine (10(-5) mol/L), or endothelin-1 (10 pmol) were found between the two groups. Relaxing responses to acetylcholine or sodium nitroprusside in phenylephrine-precontracted mesenteric vascular beds and constrictor response to the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (100 nmol) were comparable in both groups. Losartan blunted angiotensin II constriction and reduced (P < .05) responses to phenylephrine in all groups.(ABSTRACT TRUNCATED AT 250 WORDS)
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蔗糖不会升高维持低盐摄入量的大鼠的血压。
DOI：
10.1161/01.hyp.21.6.779
发表时间：
1993
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Johnson,MD;Zhang,HY;Kotchen,TA
通讯作者：
Kotchen,TA
自发性高血压大鼠肾血管紧张素 II 亚型 1 受体反应增强。
DOI：
10.1161/01.hyp.21.4.420
发表时间：
1993
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
KostJr,CK;Jackson,EK
通讯作者：
Jackson,EK
影响因子：
8.3
作者：
MARTINEZ, FJ;RIZZA, RA;ROMERO, JC
通讯作者：
ROMERO, JC
影响因子：
8.3
作者：
HWANG, IS;HO, H;REAVEN, GM
通讯作者：
REAVEN, GM