High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice
High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice
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含乳清蛋白的高钙饮食可减弱高脂肪喂养的 C57Bl/6J 小鼠的体重增加
DOI：
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发表时间：
2007
影响因子：
3.6
通讯作者：
E. Mervaala
中科院分区：
文献类型：
--
作者：
T. Pilvi;R. Korpela;Minna M. Huttunen;H. Vapaatalo;E. Mervaala
多项研究发现钙摄入量与体重指数之间存在负相关关系。有人提出，Ca 通过抑制 1,25-二羟基胆钙化醇 (1,25(OH)2-D3) 影响脂肪细胞代谢并减少脂肪吸收。我们研究了钙和乳蛋白（乳清和酪蛋白）对 C57Bl/6J 小鼠体重的影响。将 9 周龄的雄性小鼠分为三组（每组 10 只小鼠），接受改良的高脂肪（60% 能量）饮食。两组接受高钙饮食（1·8 % 碳酸钙 (CaCO3)）和酪蛋白或乳清蛋白（18 % 能量），一组接受低钙饮食（0·4 % CaCO3）和酪蛋白，持续 21 周。每天测量食物摄入量，每周测量两次体重。在研究期间，对所有小鼠的身体脂肪含量（通过双能 X 射线吸收测定法）以及七只小鼠/组的粪便钙和脂肪排泄进行了两次测量。高钙乳清组的最终体重 (44·1 (sem 1·1) g) 和体脂含量 (41·6 (sem 0·6) %) 显着低于低钙酪蛋白组 (48·1 (sem 0·8) g 和 44·9 (sem 0·8) %) (P < 0·05)。尽管高钙酪蛋白组的血清 1,25(OH)2-D3 水平均显着低于低钙酪蛋白组 (P < 0·001)，但高钙酪蛋白组的体重和体脂肪含量与低钙酪蛋白组没有显着差异。因此，血清 1,25(OH)2-D3 的变化似乎不会影响该动物模型的体重。高钙乳清组和低钙酪蛋白组之间的脂肪排泄存在显着差异（高钙乳清组为 3·9 (sem 0·9) %，低钙酪蛋白组为 1·4 (sem 0·2) %；P < 0·05），这可以部分解释对体重的影响。
An inverse relationship between Ca intake and BMI has been found in several studies. It has been suggested that Ca affects adipocyte metabolism via suppressing 1,25-dihydroxycholecalciferol (1,25(OH)2-D3) and decreases fat absorption. We studied the effect of Ca and milk proteins (whey and casein) on body weight in C57Bl/6J mice. Male mice, age 9 weeks, were divided into three groups (ten mice per group) receiving modified high-fat (60 % of energy) diets. Two groups received a high-Ca diet (1·8 % calcium carbonate (CaCO3)), with casein or whey protein (18 % of energy), and one group received a low-Ca diet (0·4 % CaCO3) with casein for 21 weeks. Food intake was measured daily and body weight twice per week. Body fat content (by dual-energy X-ray absorptiometry) of all mice and faecal Ca and fat excretion of seven mice/group were measured twice during the study. Final body weight (44·1 (sem 1·1) g) and body fat content (41·6 (sem 0·6) %) were significantly lower (P < 0·05) in the high-Ca whey group than in the low-Ca casein group (48·1 (sem 0·8) g and 44·9 (sem 0·8) %). Body weight and body fat content of the high-Ca casein group did not differ significantly from the low-Ca casein group even though serum 1,25(OH)2-D3 levels were significantly lower (P < 0·001) in both high-Ca groups than in the low-Ca casein group. Thus changes in serum 1,25(OH)2-D3 do not seem to affect body weight in this animal model. There was a significant difference in fat excretion between the high-Ca whey and low-Ca casein groups (3·9 (sem 0·9) % in the high-Ca whey v. 1·4 (sem 0·2) % in the low-Ca casein group; P < 0·05), which may partly explain the effect on body weight.
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DOI：
10.1210/jcem.85.12.7063
发表时间：
2000-12
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
K. Davies;R. Heaney;R. Recker;J. Lappe;M. Barger-Lux;K. Rafferty;S. Hinders
通讯作者：
K. Davies;R. Heaney;R. Recker;J. Lappe;M. Barger-Lux;K. Rafferty;S. Hinders
膳食钙对瘦和肥胖小鼠和大鼠的体重没有影响。
DOI：
10.1152/ajpregu.00655.2003
发表时间：
2004
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Zhang,Qinmin;Tordoff,MichaelG
通讯作者：
Tordoff,MichaelG
影响因子：
4.8
作者：
Z. Ni;M. Smogorzewski;S. Massry
通讯作者：
Z. Ni;M. Smogorzewski;S. Massry
影响因子：
15.9
作者：
Patti, ME;Brambilla, E;Kahn, CR
通讯作者：
Kahn, CR
影响因子：
5.8
作者：
Parikh, SJ;Edelman, M;Yanovski, JA
通讯作者：
Yanovski, JA