No effect of dietary calcium on body weight of lean and obese mice and rats.

No effect of dietary calcium on body weight of lean and obese mice and rats.
复制标题

膳食钙对瘦和肥胖小鼠和大鼠的体重没有影响。

DOI:
10.1152/ajpregu.00655.2003
复制
发表时间:
2004
期刊:
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子:
--
通讯作者:
Tordoff,MichaelG
Tordoff,MichaelG
中科院分区:
--
文献类型:
--
作者:
Zhang,Qinmin;Tordoff,MichaelG

文献摘要

参考文献

被引文献

相似文献

最近的流行病学和动物研究导致了一种假说,即饮食中低钙摄入量会导致肥胖。在这里,我们评估了钙是否影响正常体重和肥胖啮齿动物的体重。所有实验都涉及雌性C57BL/6J小鼠或Spraogue-Dawley大鼠,喂养正常或高能量密度的食物(3.8或4.7千卡/克)。通过允许小鼠饮用加糖的30 mM CaCl2溶液或喂养钙含量不同的小鼠和大鼠饮食(0.2%、0.6%或1.8%钙)来控制钙的摄入量。从老鼠身上采集血液样本,以确认这些饮食对新陈代谢有预期的影响。钙处理对能量摄入量、体重或体脂含量没有影响,促钙激素与体重之间也没有简单的关系。一项实验发现,喂食1.8%钙离子饮食的瘦小和肥胖大鼠的体重增加显著减少,但我们怀疑这是由于被迫食用这种令人不快的饮食,从而减少了生长。这些研究几乎不支持饮食中的钙对肥胖的病因或维持有贡献的假设。
Recent epidemiological and animal studies have led to the hypothesis that low dietary calcium intakes contribute to obesity. Here, we evaluated whether calcium influenced the body weight of normal-weight and obese rodents. All experiments involved female C57BL/6J mice or Sprague-Dawley rats fed normal- or high-energy-density diets (3.8 or 4.7 kcal/g). Calcium intake was manipulated by allowing mice to drink sweetened 30 mM CaCl2solution or feeding mice and rats diets differing in calcium content (0.2%, 0.6%, or 1.8% Ca2+). Blood samples were taken from rats to confirm that the diets had their intended effects on metabolism. There were no effects of the calcium manipulations on energy intake, body weight, or carcass fat content and no simple relation between calciotropic hormones and body weight. One experiment found a significant decrease in body weight gain of lean and obese rats fed the 1.8% Ca2+diet, but we suspect that this was due to forced consumption of the unpalatable diet, reducing growth. These studies provide little support for the hypothesis that dietary calcium contributes to the etiology or maintenance of obesity.
DOI: 10.1152/ajpregu.1993.264.3.r500
发表时间: 1993
期刊: The American journal of physiology
影响因子: --
作者:
Tordoff,MG;Hughes,RL;Pilchak,DM
通讯作者: Pilchak,DM
膳食钙对自发性高血压大鼠钠和钙摄入量的影响。
DOI: 10.1152/ajpregu.1992.262.3.r370
发表时间: 1992
期刊: The American journal of physiology
影响因子: --
作者:
Tordoff,MG
通讯作者: Tordoff,MG
钙摄入量:协变量和混杂因素。
DOI: 10.1093/ajcn/53.3.741
发表时间: 1991
期刊: The American journal of clinical nutrition
影响因子: --
作者:
Holbrook,TL;Barrett-Connor,E
通讯作者: Barrett-Connor,E
DOI: 10.1093/jn/133.1.268s
发表时间: 2003-01-01
影响因子: 4.2
作者:
Heaney, RP
通讯作者: Heaney, RP
膳食钙和钠对自发性高血压大鼠和 Wistar-Kyoto 大鼠全身脂肪的影响。
DOI: --
发表时间: 1988
影响因子: 3.2
作者:
J. Metz;Njeri Karanja;J. Torok;David A. McCarron
通讯作者: David A. McCarron