No association between arsenic exposure from drinking water and diabetes mellitus: a cross-sectional study in Bangladesh.
No association between arsenic exposure from drinking water and diabetes mellitus: a cross-sectional study in Bangladesh.
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DOI：
10.1289/ehp.0901559
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发表时间：
2010-09
影响因子：
10.4
通讯作者：
Graziano JH
中科院分区：
文献类型：
--
作者：
Chen Y;Ahsan H;Slavkovich V;Peltier GL;Gluskin RT;Parvez F;Liu X;Graziano JH
饮用水中砷暴露水平< 300 μg/L的长期影响和糖尿病风险仍然是一个有争议的话题。我们进行了一项基于人群的横断面研究，使用来自孟加拉国Araihazar砷对健康影响纵向研究的11，319名参与者的基线数据，以评估井水砷和总尿砷浓度与糖尿病和糖尿病患病率的相关性。我们还评估了井水砷，总尿砷和尿砷代谢产物的浓度与血液糖化血红蛋白（HbA 1c）水平的研究人群的子集。90%以上的队列成员接触砷浓度< 300 μg/L的饮用水。我们发现砷暴露与糖尿病患病率之间没有关联。糖尿病的调整优势比为1.00（参考），1.35 [95%置信区间（CI），0.90-2.02]，1.24（0.82-1.87）、0.96（0.62-1.49）和1.11（0.73-1.69）分别与时间加权水砷浓度为0.1-8、8-41、41-91、92-176和≥ 177 μg/L的五分位数相关，和1.00（referent），1.29（0.87-1.91）、1.05（0.69-1.59）、0.94（0.61-1.44）和0.93（0.59-1.45）。我们没有观察到砷暴露和糖尿患病率之间的关联，也没有证据表明井水砷、尿总砷或尿砷代谢产物的组成与HbA 1c水平之间存在关联。我们的研究结果并不支持从饮用水砷暴露和糖尿病的风险显着增加的范围内观察到的水平的关联。进一步的前瞻性研究将有助于证实这些发现。
The long-term effects of arsenic exposure from drinking water at levels < 300 μg/L and the risk of diabetes mellitus remains a controversial topic. We conducted a population-based cross-sectional study using baseline data from 11,319 participants in the Health Effects of Arsenic Longitudinal Study in Araihazar, Bangladesh, to evaluate the associations of well water arsenic and total urinary arsenic concentration and the prevalence of diabetes mellitus and glucosuria. We also assessed the concentrations of well water arsenic, total urinary arsenic, and urinary arsenic metabolites in relation to blood glycosylated hemoglobin (HbA1c) levels in subsets of the study population. More than 90% of the cohort members were exposed to drinking water with arsenic concentration < 300 μg/L. We found no association between arsenic exposure and the prevalence of diabetes. The adjusted odds ratios for diabetes were 1.00 (referent), 1.35 [95% confidence interval (CI), 0.90–2.02], 1.24 (0.82–1.87), 0.96 (0.62–1.49), and 1.11 (0.73–1.69) in relation to quintiles of time-weighted water arsenic concentrations of 0.1–8, 8–41, 41–91, 92–176, and ≥ 177 μg/L, respectively, and 1.00 (referent), 1.29 (0.87–1.91), 1.05 (0.69–1.59), 0.94 (0.61–1.44), and 0.93 (0.59–1.45) in relation to quintiles of urinary arsenic concentrations of 1–36, 37–66, 67–114, 115–204, and ≥ 205 μg/L, respectively. We observed no association between arsenic exposure and prevalence of glucosuria and no evidence of an association between well water arsenic, total urinary arsenic, or the composition of urinary arsenic metabolites and HbA1c level. Our findings do not support an association of arsenic exposure from drinking water and a significantly increased risk of diabetes mellitus in the range of levels observed. Further prospective studies would be valuable in confirming the findings.
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影响因子：
8.3
作者：
Coronado-Gonzalez, Jose Antonio;Del Razo, Luz Maria;la Pena, Jorge Escobedo-de
通讯作者：
la Pena, Jorge Escobedo-de
影响因子：
8.3
作者：
CHEN, CJ;HSUEH, YM;TAI, TY
通讯作者：
TAI, TY
影响因子：
11.8
作者：
Das, HK;Mitra, AK;Rabbani, GH
通讯作者：
Rabbani, GH
影响因子：
5.7
作者：
Edelman, D;Olsen, MK;Oddone, EZ
通讯作者：
Oddone, EZ
影响因子：
8.7
作者：
Chen, CJ;Chiou, HY;Tai, TY
通讯作者：
Tai, TY