Effect of a history of major depressive disorder on smoking-induced dopamine release.
Effect of a history of major depressive disorder on smoking-induced dopamine release.
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DOI：
10.1016/j.biopsych.2009.06.011
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发表时间：
2009-11-01
影响因子：
10.6
通讯作者：
Mandelkern, Mark A.
中科院分区：
文献类型：
--
作者：
Brody, Arthur L.;Olmstead, Richard E.;Abrams, Anna L.;Costello, Matthew R.;Khan, Aliyah;Kozman, Daniel;Saxena, Sanjaya;Farahi, Judah;London, Edythe D.;Mandelkern, Mark A.
关键词：
Dopamine (DA) system dysfunction is implicated in the pathophysiology of Major Depressive Disorder (MDD). We sought to determine if cigarette smokers with a history of MDD and current mild depressive symptoms have abnormal smoking-induced DA release (measured indirectly as change in 11C-raclopride binding potential [BPND]). Fifty-six cigarette smokers either with (n = 10) or without (n = 46) a history of MDD (MDD+ and MDD−, respectively) underwent bolus-plus-continuous-infusion 11C-raclopride positron emission tomography, during which they smoked a regular cigarette. Pre- to post- smoking changes in 11C-raclopride BPND were compared between groups. Also, correlations were determined between change in BPND and depression, anxiety, and withdrawal rating scale scores for the MDD+ group. The MDD+ group had a significantly greater reduction in 11C-raclopride BPND (−16.3%) than the MDD− group (−8.4%) (ANCOVA, p = 0.03). Significant negative correlations were found between depression/anxiety and change in 11C-raclopride BPND (r = −0.77, p < 0.01 and r = −0.74, p = 0.01, respectively). MDD+ smokers have greater smoking-induced DA release than MDD− smokers, and higher depression/anxiety levels are associated with greater smoking-induced DA release. These findings support the theory that MDD+ smokers have DA system dysfunction including heightened smoking-induced DA release.
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影响因子：
10.6
作者：
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