Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study.
Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study.
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DOI：
10.1016/j.envint.2018.09.027
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发表时间：
2018-12
影响因子：
11.8
通讯作者：
Harley KG
中科院分区：
文献类型：
--
作者：
Berger K;Eskenazi B;Balmes J;Holland N;Calafat AM;Harley KG
个人护理产品的化学物质可能会导致哮喘和其他特应性疾病的风险。现有的文献是相互矛盾的，许多研究没有控制多重化学品暴露。我们量化了三种邻苯二甲酸酯代谢物，三种对羟基苯甲酸酯和其他四种酚类化合物的浓度，在怀孕期间从392名妇女的尿液中收集了两次。我们测量了他们的孩子在2岁、5岁和7岁时血液中的辅助性T细胞1（Th 1）和辅助性T细胞2（Th 2），并评估了7岁时可能的哮喘、空气过敏、湿疹和肺功能。我们进行了线性和逻辑回归，控制了通过贝叶斯模型平均选择的在该人群中测量的其他生物标志物。大多数比较显示无效关联。邻苯二甲酸单丁酯（MnBP）与较高的Th2%相关（RR：10.40，95% CI：3.37，17.92），对羟基苯甲酸甲酯与较低的Th1%（RR：-3.35，95% CI：-6.58，-0.02）和Th2%相关（RR：-4.45，95% CI：-8.77，0.08）。邻苯二甲酸单乙酯与用力呼气流量较低相关，为用力肺活量的25-75%（FEF 25 -75%）（RR：−3.22升/秒，95% CI：−6.02，−0.34）。对羟基苯甲酸丙酯（OR：0.86，95% CI：0.74，0.99）与可能的哮喘几率降低相关。虽然一些生物标志物，特别是来自低分子量邻苯二甲酸酯的生物标志物，与特应性细胞因子谱和较差的肺功能相关，但没有生物标志物与特应性疾病的相应增加相关。
Personal care product chemicals may be contributing to risk for asthma and other atopic illnesses. The existing literature is conflicting, and many studies do not control for multiple chemical exposures. We quantified concentrations of three phthalate metabolites, three parabens, and four other phenols in urine collected twice during pregnancy from 392 women. We measured T helper 1 (Th1) and T helper 2 (Th2) cells in their children’s blood at ages two, five, and seven, and assessed probable asthma, aeroallergies, eczema, and lung function at age seven. We conducted linear and logistic regressions, controlling for additional biomarkers measured in this population as selected by Bayesian Model Averaging. The majority of comparisons showed null associations. Mono-n-butyl phthalate (MnBP) was associated with higher Th2% (RR: 10.40, 95% CI: 3.37, 17.92), and methyl paraben was associated with lower Th1% (RR: −3.35, 95% CI: −6.58, −0.02) and Th2% at borderline significance (RR: −4.45, 95% CI: −8.77, 0.08). Monoethyl phthalate was associated with lower forced expiratory flow from 25–75% of forced vital capacity (FEF25–75%) (RR: −3.22 liters/second, 95% CI: −6.02, −0.34). Propyl paraben (OR: 0.86, 95% CI: 0.74, 0.99) was associated with decreased odds of probable asthma. While some biomarkers, particularly those from low molecular weight phthalates, were associated with an atopic cytokine profile and poorer lung function, no biomarkers were associated with a corresponding increase in atopic disease.
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影响因子：
13.6
作者：
Duijts, Liesbeth
通讯作者：
Duijts, Liesbeth
DOI：
10.4103/0970-2113.63609
发表时间：
2010-04
期刊：
Lung India : official organ of Indian Chest Society
影响因子：
--
作者：
Deo SS;Mistry KJ;Kakade AM;Niphadkar PV
通讯作者：
Niphadkar PV
影响因子：
8
作者：
Akinbami, Lara J.;Moorman, Jeanne E.;Sondik, Edward J.
通讯作者：
Sondik, Edward J.
DOI：
10.4168/aair.2010.2.3.183
发表时间：
2010-07
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Cho YS;Moon HB
通讯作者：
Moon HB
影响因子：
2.5
作者：
Cone, Edward J.;Caplan, Yale H.;Black, David L.
通讯作者：
Black, David L.