Benefit of multiple sessions of perilesional repetitive transcranial magnetic stimulation for an effective rehabilitation of visuospatial function.
Benefit of multiple sessions of perilesional repetitive transcranial magnetic stimulation for an effective rehabilitation of visuospatial function.
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DOI：
10.1111/ejn.12055
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Valero-Cabré A
中科院分区：
文献类型：
--
作者：
Afifi L;Jarrett Rushmore R;Valero-Cabré A
非侵入性神经刺激技术已被单独使用或与康复治疗结合使用，以治疗脑损伤的神经系统后遗症，治疗结果差异较大。限制这种技术持续成功的一个潜在因素可能是在患者中进行的会话很少，尽管有报告称其累积可能在长期缓解神经功能缺损方面发挥关键作用。在这项研究中，我们测试了70个连续会议的病灶周围高频（10 Hz）重复经颅磁刺激（rTMS）在治疗慢性忽视缺陷的视觉空间忽视的一个完善的猫模型的影响。在相同的rTMS参数和视觉空间测试制度下，一半的受试者在视觉空间定向性能提高。另一半人在被忽视的半空间中没有或非常温和地改善，并表现出短暂的适应不良的视觉空间行为模式。详细的分析表明，病变的位置和程度并不能解释这两组动物之间观察到的行为差异。我们的结论是，多会话perilesional rTMS制度有可能诱导功能改善局灶性慢性脑损伤后，和行为表现之前的rTMS治疗的发病是最好的预测积极的结果的因素，非侵入性神经刺激治疗视觉空间忽视。
Non-invasive neurostimulation techniques have been used alone or in conjunction with rehabilitation therapy to treat the neurological sequelae of brain damage with rather variable therapeutic outcomes. One potential factor limiting a consistent success for such techniques may be the few sessions carried out in patients, despite reports that their accrual may play a key role in alleviating neurological deficits long-term. In this study, we tested the effects of seventy consecutive sessions of perilesional high frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS) in the treatment of chronic neglect deficits in a well-established feline model of visuo-spatial neglect. Under identical rTMS parameters and visuo-spatial testing regimes, half of the subjects improved in visuo-spatial orienting performance. The other half experienced either none or extremely moderate ameliorations in the neglected hemispace and displayed transient patterns of maladaptive visuo-spatial behavior. Detailed analyses suggest that lesion location and extent did not account for the behavioral differences observed between these two groups of animals. We conclude that multi-session perilesional rTMS regimes have the potential to induce functional ameliorations following focal chronic brain injury, and that behavioral performance prior to the onset of the rTMS treatment is the factor that best predicts positive outcomes for non-invasive neurostimulation treatments in visuo-spatial neglect.
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影响因子：
1.7
作者：
Fregni, F;Boggio, PS;Pascual-Leone, A
通讯作者：
Pascual-Leone, A
DOI：
10.1523/jneurosci.0316-12.2012
发表时间：
2012-04-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Das A;Demagistris M;Huxlin KR
通讯作者：
Huxlin KR
影响因子：
3.7
作者：
Huxlin, KR;Pasternak, T
通讯作者：
Pasternak, T
影响因子：
5.5
作者：
Moliadze, V;Zhao, YQ;Funke, K
通讯作者：
Funke, K
影响因子：
9.9
作者：
Mansur, CG;Fregni, F;Pascual-Leone, A
通讯作者：
Pascual-Leone, A