Cognitive tasks and human ambulatory electrocorticography using the RNS System.
Cognitive tasks and human ambulatory electrocorticography using the RNS System.
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DOI：
10.1016/j.jneumeth.2018.09.026
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发表时间：
2019-01-01
影响因子：
3
通讯作者：
Jobst BC
中科院分区：
文献类型：
--
作者：
Meisenhelter S;Testorf ME;Gorenstein MA;Hasulak NR;Tcheng TK;Aronson JP;Jobst BC
皮质电描记术研究通常在接受视频EEG监测的患者中进行，但这些研究容易受到混淆，例如疼痛、近期麻醉、镇痛药、药物变化、抗生素和植入物效应的影响。开发了技术以从使用RNS®系统（NeuroPace，Inc.，山景，CA），一种脑响应神经刺激医疗器械，用于治疗局灶性癫痫，并将来自RNS系统的数据与认知任务事件高精度对齐。这些受试者近期未接受手术，因此未受到影响视频EEG研究的围手术期变量的混淆。使用同步标记技术的任务同步提供了时钟不确定性的定量测量，并且可以将数据与不确定性小于4 ms的任务事件对齐。研究人员发现，与正确反应前的海马活动相比，在对数学问题做出错误反应前，海马ECoG活动会立即发生变化。此外，受试者被发现有可变的，但显着的变化，θ带功率在海马导航期间相比，当受试者不导航。我们发现，有theta-gamma相位振幅耦合在右侧海马体，而受试者站着不动，在导航任务。在这项研究中描述的对齐技术提高了任务ECoG对齐不确定性的上限从大约30毫秒到4毫秒以下。RNS系统是首批能够为人类提供不受限制的动态ECoG记录的平台之一，允许研究真实的世界，而不是虚拟导航。与颅内视频EEG研究相比，使用RNS系统平台的研究不会受到围手术期环境固有的药物和近期手术引起的混淆。此外，这些主题提供了多年来从相同电极记录的机会。RNS系统使我们能够以前所未有的清晰度研究人类导航。虽然RNS系统患者植入的电极比视频EEG患者少，但由于缺乏外部伪影和近期手术造成的混淆，该系统成为进一步开展人体电生理学研究的有用工具。皮质电描记术研究通常在接受视频EEG监测的患者中进行，但这些研究容易受到混淆，例如疼痛、近期麻醉、镇痛药、药物变化、抗生素和植入物效应的影响。我们开发了使用NeuroPace RNS®系统（一种用于治疗部分发作癫痫的脑响应神经刺激系统）的技术，以从在研究环境中执行导航任务的自由移动受试者中获得皮层电图（ECoG）数据。使用同步标记技术的任务同步提供了时钟不确定性的定量测量，并且可以将数据与不确定性小于4 ms的任务事件对齐。我们发现，海马ECoG活动的变化过程中的自由回忆任务的一部分，在导航。在这项研究中描述的对齐技术提高了任务ECoG对齐不确定性的上限从大约30毫秒到4毫秒以下。RNS系统是首批能够为人体提供无束缚动态ECoG记录的平台之一，允许研究真实的世界，而不是虚拟导航。RNS系统使我们能够以前所未有的清晰度研究人类导航。虽然RNS系统患者植入的电极比视频EEG患者少，但由于缺乏外部伪影和近期手术造成的混淆，该系统成为进一步开展人体电生理学研究的有用工具。
Electrocorticography studies are typically conducted in patients undergoing video EEG monitoring, but these studies are subject to confounds such as the effects of pain, recent anesthesia, analgesics, drug changes, antibiotics, and implant effects. Techniques were developed to obtain electrocorticographic (ECoG) data from freely moving subjects performing navigational tasks using the RNS® System (NeuroPace, Inc., Mountain View, CA), a brain-responsive neurostimulation medical device used to treat focal onset epilepsy, and to align data from the RNS System with cognitive task events with high precision. These subjects had not had recent surgery, and were therefore not confounded by the perioperative variables that affect video EEG studies. Task synchronization using the synchronization marker technique provides a quantitative measure of clock uncertainty, and can align data to task events with less than 4ms of uncertainty. Hippocampal ECoG activity was found to change immediately before an incorrect response to a math problem compared to hippocampal activity before a correct response. In addition, subjects were found to have variable but significant changes in theta band power in the hippocampus during navigation compared to when subjects were not navigating. We found that there is theta-gamma phase-amplitude coupling in the right hippocampus while subjects stand still during a navigation task. An alignment technique described in this study improves the upper bound on task-ECoG alignment uncertainty from approximately 30ms to under 4ms. The RNS System is one of the first platforms capable of providing untethered ambulatory ECoG recording in humans, allowing for the study of real world instead of virtual navigation. Compared to intracranial video EEG studies, studies using the RNS System platform are not subject to confounds caused by the drugs and recent surgery inherent to the perioperative environment. Furthermore, these subjects provide the opportunity to record from the same electrodes over the course of many years. The RNS System enables us to study human navigation with unprecedented clarity. While RNS System patients have fewer electrodes implanted than video EEG patients, the lack of external artifact and confounds from recent surgery make this system a useful tool to further human electrophysiology research. Electrocorticography studies are typically conducted in patients undergoing video EEG monitoring, but these studies are subject to confounds such as the effects of pain, recent anesthesia, analgesics, drug changes, antibiotics, and implant effects. We developed techniques for using the NeuroPace RNS® System, a brain-responsive neurostimulation system to treat partial onset epilepsy, to obtain electrocorticographic (ECoG) data from freely moving subjects performing navigational tasks in a research setting. Task synchronization using the synchronization marker technique provides a quantitative measure of clock uncertainty, and can align data to task events with less than 4ms of uncertainty. We found that hippocampal ECoG activity changes during parts of a free recall task and during navigation. An alignment technique described in this study improves the upper bound on task-ECoG alignment uncertainty from approximately 30ms to under 4ms. The RNS System is one of the first platforms capable of providing untethered ambulatory ECoG recording in humans, allowing for the study of real world instead of virtual navigation. The RNS System enables us to study human navigation with unprecedented clarity. While RNS System patients have fewer electrodes implanted than video EEG patients, the lack of external artifact and confounds from recent surgery make this system a useful tool to further human electrophysiology research.
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DOI：
10.1016/j.cub.2017.03.028
发表时间：
2017-05-08
期刊：
Current biology : CB
影响因子：
--
作者：
Ezzyat Y;Kragel JE;Burke JF;Levy DF;Lyalenko A;Wanda P;O'Sullivan L;Hurley KB;Busygin S;Pedisich I;Sperling MR;Worrell GA;Kucewicz MT;Davis KA;Lucas TH;Inman CS;Lega BC;Jobst BC;Sheth SA;Zaghloul K;Jutras MJ;Stein JM;Das SR;Gorniak R;Rizzuto DS;Kahana MJ
通讯作者：
Kahana MJ
侧向海马振荡是人类空间记忆和导航的不同方面的基础。
影响因子：
16.6
作者：
Miller J;Watrous AJ;Tsitsiklis M;Lee SA;Sheth SA;Schevon CA;Smith EH;Sperling MR;Sharan A;Asadi-Pooya AA;Worrell GA;Meisenhelter S;Inman CS;Davis KA;Lega B;Wanda PA;Das SR;Stein JM;Gorniak R;Jacobs J
通讯作者：
Jacobs J
影响因子：
16.2
作者：
Sirota A;Montgomery S;Fujisawa S;Isomura Y;Zugaro M;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
--
作者：
Lachaux, JP;Rudrauf, D;Kahane, P
通讯作者：
Kahane, P
影响因子：
3.5
作者：
Lega, Bradley C.;Jacobs, Joshua;Kahana, Michael
通讯作者：
Kahana, Michael