Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation.
Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation.
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侧向海马振荡是人类空间记忆和导航的不同方面的基础。
DOI：
10.1038/s41467-018-04847-9
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发表时间：
2018-06-21
影响因子：
16.6
通讯作者：
Jacobs J
中科院分区：
文献类型：
--
作者：
Miller J;Watrous AJ;Tsitsiklis M;Lee SA;Sheth SA;Schevon CA;Smith EH;Sperling MR;Sharan A;Asadi-Pooya AA;Worrell GA;Meisenhelter S;Inman CS;Davis KA;Lega B;Wanda PA;Das SR;Stein JM;Gorniak R;Jacobs J
海马在认知的各个方面起着至关重要的作用，包括记忆和空间导航。为了从电生理学上了解海马体是如何支持这些过程的，我们记录了46名神经外科患者在执行空间记忆任务时的颅内脑电图活动。我们测量来自多个大脑区域的信号，包括左和右前额叶，我们使用频谱分析来识别与记忆编码和导航相关的振荡模式。我们发现，在左侧而不是右侧海马，在1 - 3-Hz的"低θ"带的振荡幅度增加时，查看随后记住的对象位置对。相比之下，在右侧而不是左侧海马体中，低θ活动在导航期间增加。这些海马信号的频率比新皮层中与任务相关的信号慢。这些结果表明，人类大脑包括多个支持认知不同方面的侧化振荡网络。θ振荡与记忆形成有关。在这里，作者表明，海马体中的低θ振荡在每个半球之间受到不同的调制，当成功学习物体位置对时，左侧的振荡增加，而在空间导航期间，右侧的振荡增加。
The hippocampus plays a vital role in various aspects of cognition including both memory and spatial navigation. To understand electrophysiologically how the hippocampus supports these processes, we recorded intracranial electroencephalographic activity from 46 neurosurgical patients as they performed a spatial memory task. We measure signals from multiple brain regions, including both left and right hippocampi, and we use spectral analysis to identify oscillatory patterns related to memory encoding and navigation. We show that in the left but not right hippocampus, the amplitude of oscillations in the 1–3-Hz “low theta” band increases when viewing subsequently remembered object–location pairs. In contrast, in the right but not left hippocampus, low-theta activity increases during periods of navigation. The frequencies of these hippocampal signals are slower than task-related signals in the neocortex. These results suggest that the human brain includes multiple lateralized oscillatory networks that support different aspects of cognition. Theta oscillations are implicated in memory formation. Here, the authors show that low-theta oscillations in the hippocampus are differentially modulated between each hemisphere, with oscillations in the left increasing when successfully learning object–location pairs and in the right during spatial navigation.
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DOI：
10.1016/j.cub.2017.03.028
发表时间：
2017-05-08
期刊：
Current biology : CB
影响因子：
--
作者：
Ezzyat Y;Kragel JE;Burke JF;Levy DF;Lyalenko A;Wanda P;O'Sullivan L;Hurley KB;Busygin S;Pedisich I;Sperling MR;Worrell GA;Kucewicz MT;Davis KA;Lucas TH;Inman CS;Lega BC;Jobst BC;Sheth SA;Zaghloul K;Jutras MJ;Stein JM;Das SR;Gorniak R;Rizzuto DS;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
3.2
作者：
Jacobs J;Korolev IO;Caplan JB;Ekstrom AD;Litt B;Baltuch G;Fried I;Schulze-Bonhage A;Madsen JR;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
5.3
作者：
Cornwell, Brian R.;Johnson, Linda L.;Grillon, Christian
通讯作者：
Grillon, Christian
影响因子：
3.5
作者：
Buzsáki, G
通讯作者：
Buzsáki, G
影响因子：
25
作者：
Bonnevie, Tora;Dunn, Benjamin;Moser, May-Britt
通讯作者：
Moser, May-Britt