Role of amygdala dopamine D1 and D2 receptors in the acquisition and expression of fructose-conditioned flavor preferences in rats.
Role of amygdala dopamine D1 and D2 receptors in the acquisition and expression of fructose-conditioned flavor preferences in rats.
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DOI：
10.1016/j.bbr.2009.06.032
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发表时间：
2009-12-14
影响因子：
2.7
通讯作者：
Bodnar, Richard J.
中科院分区：
文献类型：
--
作者：
Bernal, Sonia;Miner, Patricia;Abayev, Yana;Kandova, Ester;Gerges, Meri;Touzani, Khalid;Sclafani, Anthony;Bodnar, Richard J.
Systemic administration of dopamine D1-like (SCH23390) and, to a lesser degree D2-like (raclopride), receptor antagonists significantly reduce the acquisition and expression of fructose-conditioned flavor preferences (CFP) in rats. Given the role of dopamine in the amygdala (AMY) in the processing and learning of food reward, the present study examined whether dopamine D1-like or D2-like antagonists in this site altered acquisition and/or expression of a fructose-CFP. In Experiment 1, food-restricted rats with bilateral AMY cannulae were trained to drink a fructose (8%) + saccharin (0.2%) solution mixed with one flavor (e.g., grape, CS+/Fs) and a less-preferred 0.2% saccharin solution mixed with another flavor (e.g., cherry, CS-/s) during one-bottle (16 ml) sessions. Two-bottle tests with the two flavors mixed in saccharin solutions (CS+/s, CS-/s) occurred 10 min following total bilateral AMY doses of 0, 12, 24 and 48 nmol of SCH23390 or raclopride. Preference for CS+/s over CS-/s was significantly reduced relative to vehicle baseline by the 48 nmol doses of SCH23390 and raclopride (from 77% to 66% and 68%), but not lower doses. In Experiment 2, rats received bilateral AMY injections (12 nmol) of SCH23390 (D1 group) or raclopride (D2 group) 10 min prior to one-bottle training sessions with CS+/Fs and CS-/s. Yoked control rats received vehicle and were limited to the CS intakes of the D1 and D2 groups; untreated controls were not injected or limited to drug group intakes during training. Subsequent two-bottle tests revealed initial preferences of CS+/s over CS-/s in all groups that remained stable in untreated and yoked controls, but were lost over the 6 tests sessions in the D1 group, but not in the D2 group. These data indicate that dopamine D1-like and D2-like antagonists significantly attenuated the expression of the previously-acquired fructose-CFP, and did not block acquisition of the fructose-CFP. D1-like antagonism during training hastened extinction of the fructose-CFP. The results are similar to those produced by dopamine D1-like and D2-like antagonist injections into the nucleus accumbens shell which suggests that flavor conditioning involves a regionally-distributed brain network.
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影响因子：
3.6
作者：
Azzara, AV;Bodnar, RJ;Sclafani, A
通讯作者：
Sclafani, A
影响因子：
3.3
作者：
Bassareo, V;Di Chiara, G
通讯作者：
Di Chiara, G
DOI：
10.1017/cbo9780511541643.009
发表时间：
2008-01-01
期刊：
NEUROBIOLOGY OF OBESITY
影响因子：
--
作者：
Bodnar, Richard J.;Levine, Allen S.
通讯作者：
Levine, Allen S.
影响因子：
2
作者：
Cheng, J;Feenstra, MGP
通讯作者：
Feenstra, MGP
影响因子：
3.4
作者：
Bassareo, V;Di Chiara, G
通讯作者：
Di Chiara, G