Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia.
Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia.
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DOI：
10.3389/fnhum.2020.597694
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发表时间：
2020
影响因子：
2.9
通讯作者：
Henry ML
中科院分区：
文献类型：
--
作者：
Dial HR;Gnanateja GN;Tessmer RS;Gorno-Tempini ML;Chandrasekaran B;Henry ML
缺语变异型原发性进行性失语症（lvPPA）是一种以语音加工受损为主要特征的神经退行性语言障碍。在lvPPA中观察到句子重复和理解缺陷，并与受损的语音工作记忆有关，但最近的证据也表明言语感知受损。目前，在lvPPA中，形成感知支架的语音包络的神经编码还不清楚。我们利用电生理学的最新分析进展来检查lvPPA中的语音包络编码。我们评估了皮质跟踪的语音包络和任务中的理解两个口头叙述的个人lvPPA（n = 10）和年龄匹配（n = 10）的控制。尽管与对照组相比，叙述理解明显降低，但lvPPA患者在θ振荡中对语音包络的皮层跟踪增加，这种皮层跟踪低水平特征（例如，音节），而不是δ振荡，其跟踪在较长时间尺度上展开的语音单元（例如，单词、短语、韵律）。这种神经信号在叙述中高度相关。结果表明，在语音编码过程中增加了对声学线索的依赖。这可能反映了自下而上的语音线索的编码效率低下，可能是颞顶皮层功能失调的结果。
Logopenic variant primary progressive aphasia (lvPPA) is a neurodegenerative language disorder primarily characterized by impaired phonological processing. Sentence repetition and comprehension deficits are observed in lvPPA and linked to impaired phonological working memory, but recent evidence also implicates impaired speech perception. Currently, neural encoding of the speech envelope, which forms the scaffolding for perception, is not clearly understood in lvPPA. We leveraged recent analytical advances in electrophysiology to examine speech envelope encoding in lvPPA. We assessed cortical tracking of the speech envelope and in-task comprehension of two spoken narratives in individuals with lvPPA (n = 10) and age-matched (n = 10) controls. Despite markedly reduced narrative comprehension relative to controls, individuals with lvPPA had increased cortical tracking of the speech envelope in theta oscillations, which track low-level features (e.g., syllables), but not delta oscillations, which track speech units that unfold across a longer time scale (e.g., words, phrases, prosody). This neural signature was highly correlated across narratives. Results indicate an increased reliance on acoustic cues during speech encoding. This may reflect inefficient encoding of bottom-up speech cues, likely as a consequence of dysfunctional temporoparietal cortex.
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影响因子：
25
作者：
通讯作者：
--
影响因子：
9.8
作者：
Gross J;Hoogenboom N;Thut G;Schyns P;Panzeri S;Belin P;Garrod S
通讯作者：
Garrod S
影响因子：
3.4
作者：
Lalor, Edmund C.;Foxe, John J.
通讯作者：
Foxe, John J.
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4.2
作者：
Agosta, Federica;Galantucci, Sebastiano;Filippi, Massimo
通讯作者：
Filippi, Massimo
影响因子：
5.3
作者：
Fuglsang, Soren A.;Marcher-Rorsted, Jonatan;Hjortkjaer, Jens
通讯作者：
Hjortkjaer, Jens