Vaccination reduces viral load and accelerates viral clearance in SARS-CoV-2 Delta variant-infected patients.
Vaccination reduces viral load and accelerates viral clearance in SARS-CoV-2 Delta variant-infected patients.
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DOI：
10.1080/07853890.2023.2166681
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发表时间：
2023-12
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
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作者：
本研究的目的是调查疫苗在缓解 SARS-CoV-2 delta (B.1.617.2) 变种患者症状方面的有效性。在这项回顾性研究中，31名患者没有接受任何疫苗（non-vaccination，NV），21名患者接受了1剂灭活疫苗（one-dosevaccine，OV），60名患者接受了至少2剂灭活疫苗（two-dosevacation，TV）。收集并分析基线数据、临床结果和疫苗接种信息。 OV组的患者比其他两组的患者年轻（p = 0.001），但三组之间的任何其他基线数据均无显着差异。 TV组显示出比NV和OV组更高的IgG抗体水平和SARS-CoV-2周期阈值（p<0.01），TV组达到病毒载量峰值的时间（3.5±2.3天）比NV组（4.8±2.8天）和OV组（4.8±2.9天）短， p = 0.03）。电视组患者（18%）在不接受药物治疗的情况下表现出较高的康复率（p<0.001）。 TV组的病毒清除时间和住院时间显着短于NV和OV组(p < 0.01)，OV和NV组之间这些参数没有显着差异，但OV组的IgG值较高(p = 0.025)。本研究中没有发生严重并发症。在这项研究中，我们的结果表明，两剂疫苗接种可以降低病毒载量并加速病毒清除，并且两剂疫苗接种增强了体内 IgG 抗体的保护作用；然而，一剂疫苗接种并不能产生保护作用。我们的结果表明，2 剂疫苗接种可以减少 Delta 变体患者的病毒载量并加速病毒清除，并增强 IgG 抗体在体内提供的保护。
The purpose of this study was to investigate vaccine effectiveness in relieving symptoms in patients with the SARS-CoV-2 delta (B.1.617.2) variant. In this retrospective study, 31 patients did not receive any vaccine (non-vaccination, NV), 21 patients received 1-dose of inactivated vaccine (one-dose vaccination, OV), and 60 patients received at least 2-dose inactivated vaccine (two-dose vaccination, TV). The baseline data, clinical outcomes and vaccination information were collected and analyzed. Patients in the OV group were younger than those in the other two groups (p = 0.001), but there was no significant difference in any of the other baseline data among the three groups. The TV group showed higher IgG antibody levels and cycle threshold values of SARS-CoV-2 than the NV and OV groups (p < 0.01), and time to peak viral load was shorter in the TV group (3.5 ± 2.3 d) than in the NV (4.8 ± 2.8 d) and OV groups (4.8 ± 2.9 d, p = 0.03). The patients in the TV group (18%) showed a higher recovery rate without drug therapy (p < 0.001). Viral clearance time and hospital stay were significantly shorter in the TV group than in the NV and OV groups (p < 0.01), and there were no significant differences in these parameters between the OV and NV groups, but IgG values were higher in the OV group (p = 0.025). No severe complications occurred in this study. In this study, our results shows that two-dose vaccination can reduce viral loads and accelerate viral clearance, and two-dose vaccination enhance the protection of IgG antibodies in vivo; however, one-dose vaccination did not confer protective effectiveness. Our results suggest that 2-dose vaccination can reduce viral load and accelerate viral clearance in patients with the delta variant and enhance the protection afforded by IgG antibodies in vivo.
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影响因子：
82.9
作者：
Levine-Tiefenbrun, Matan;Yelin, Idan;Kishony, Roy
通讯作者：
Kishony, Roy
DOI：
10.1016/j.ijid.2021.03.083
发表时间：
2021-05
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
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作者：
Trachootham D;Thongyen S;Lam-Ubol A;Chotechuang N;Pongpirul W;Prasithsirikul W
通讯作者：
Prasithsirikul W
低湿度期间控制由 Delta 变种引起的 COVID-19 爆发的挑战：澳大利亚悉尼的一项观察性研究。
影响因子：
8.1
作者：
Ward MP;Liu Y;Xiao S;Zhang Z
通讯作者：
Zhang Z
影响因子：
5.5
作者：
Raman R;Patel KJ;Ranjan K
通讯作者：
Ranjan K
DOI：
10.1111/ajt.16641
发表时间：
2022-01
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
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