The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.
The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.
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DOI：
10.4049/jimmunol.1203163
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发表时间：
2013-03-15
期刊：
影响因子：
--
通讯作者：
Zhang W
中科院分区：
文献类型：
--
作者：
Ou-Yang CW;Zhu M;Sullivan SA;Fuller DM;Zhang W
Linker for activation of T cells (LAT) is a transmembrane adaptor protein that links T cell receptor (TCR) engagement to downstream signaling events. While it is clear that LAT is essential in thymocyte development and initiation of T cell activation, its function during T cell expansion, contraction, and memory formation remains unknown. To study the role of TCR-mediated signaling in CD8 T cells during the course of pathogen infection, we used an inducible mouse model to delete LAT in antigen-specific CD8 T cells at different stages of Listeria infection and analyzed the effect of deletion on T cell responses. Our data showed that LAT is important for maintaining CD8 T cell expansion during the priming phase; however, it is not required for CD8 T cell contraction and memory maintenance. Moreover, LAT deficiency accelerates memory differentiation during the effector-to-memory transition, leading to a higher frequency of KLRG1lowIL-7RhighCD62Lhigh memory T cells. Nonetheless, these LAT-deficient memory T cells were unable to proliferate or produce cytokines upon secondary infection. Our data demonstrated that, while it is dispensable for contraction and memory maintenance, TCR-mediated signaling regulates CD8 T cell memory differentiation and is essential for the memory response against pathogens.
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DOI：
10.1073/pnas.2336198100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Pellegrini, M;Belz, G;Strasser, A
通讯作者：
Strasser, A
影响因子：
4.8
作者：
Shen, Shudan;Chuck, Mariana I.;Zhang, Weiguo
通讯作者：
Zhang, Weiguo
影响因子：
30.5
作者：
Kaech, SM;Ahmed, R
通讯作者：
Ahmed, R
DOI：
10.1084/jem.179.1.317
发表时间：
1994-01-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Müllbacher A
通讯作者：
Müllbacher A
影响因子：
32.4
作者：
Finco, TS;Kadlecek, T;Weiss, A
通讯作者：
Weiss, A