fMRI as a molecular imaging procedure for the functional reorganization of motor systems in chronic stroke.
fMRI as a molecular imaging procedure for the functional reorganization of motor systems in chronic stroke.
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DOI：
10.3892/mmr.2013.1603
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发表时间：
2013-09
影响因子：
3.4
通讯作者：
Tzika A
中科院分区：
文献类型：
--
作者：
Lazaridou A;Astrakas L;Mintzopoulos D;Khanchiceh A;Singhal A;Moskowitz M;Rosen B;Tzika A
之前的脑成像研究表明，中风改变了运动执行网络中的功能连接。此外，目前对大脑可塑性的了解导致了中风康复的新方法。最近的研究表明，卒中后患者SMA(辅助运动区)和M1(初级运动皮质)网络中神经元活动的有效耦合对运动结果具有重要作用。皮质下卒中后，运动过程中的功能磁共振成像(FMRI)显示与功能恢复相关的皮质重组。本研究的目的是结合运动功能磁共振成像和一种新的MR相容手感机器人设备(MR_CHIROD)训练，探索运动相关区域内连接性的变化。患者在家中完成训练，并在基线和训练8周后进行系列MR评估。家庭训练包括用瘫痪患者的手以最大力量的~75%挤压凝胶练习球，每天1h，每周3天。FMRI分析显示，训练后中风患者和健康对照组的M1、SMA、PMC(运动前皮质)和Cer(小脑)都发生了变化。本研究的结果表明，SMA活性的增强可能有利于卒中幸存者的M1功能障碍。这些结果还表明，运动区之间的连接改变可能有助于抵消慢性卒中幸存者和可能有运动功能障碍的其他患者的功能异常M1。
Previous brain imaging studies suggest that stroke alters functional connectivity in motor execution networks. Moreover, current understanding of brain plasticity has led to new approaches in stroke rehabilitation. Recent studies showed a significant role of effective coupling of neuronal activity in the SMA (supplementary motor area) and M1 (primary motor cortex) network for motor outcome in patients after stroke. After a subcortical stroke, functional magnetic resonance imaging (fMRI) during movement reveals cortical reorganization that is associated with the recovery of function. The aim of the present study was to explore connectivity alterations within the motor-related areas combining motor fMRI with a novel MR-compatible hand-induced robotic device (MR_CHIROD) training. Patients completed training at home and underwent serial MR evaluation at baseline and after 8 weeks of training. Training at home consisted of squeezing a gel exercise ball with the paretic hand at ~75% of maximum strength for 1 h/day, 3 days/week. The fMRI analysis revealed alterations in M1, SMA, PMC (premotor cortex) and Cer (cerebellum) in both stroke patients and healthy controls after the training. Findings of the present study suggest that enhancement of SMA activity could benefit M1 dysfunction in stroke survivors. These results also indicate that connectivity alterations between motor areas might assist the counterbalance of a functionally abnormal M1 in chronic stroke survivors and possibly other patients with motor dysfunction.
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影响因子：
4.8
作者：
Cramer, SC;Weisskoff, RM;Rosen, BR
通讯作者：
Rosen, BR
DOI：
10.1016/j.apmr.2003.11.028
发表时间：
2004-07-01
影响因子：
4.3
作者：
Fasoli, SE;Krebs, HI;Hogan, N
通讯作者：
Hogan, N
DOI：
10.2174/1874440000802010094
发表时间：
2008-09-27
期刊：
The open neuroimaging journal
影响因子：
--
作者：
Mintzopoulos, Dionyssios;Khanicheh, Azadeh;Tzika, A Aria
通讯作者：
Tzika, A Aria
通过结合 fMRI 和 MR 兼容的手动机器人来评估慢性中风的连接改变。
影响因子：
5.7
作者：
Mintzopoulos, Dionyssios;Astrakas, Loukas G.;Khanicheh, Azadeh;Konstas, Angelos A.;Singhal, Aneesh;Moskowitz, Michael A.;Rosen, Bruce R.;Tzika, A. Aria
通讯作者：
Tzika, A. Aria
影响因子：
11.2
作者：
CHOLLET, F;DIPIERO, V;FRACKOWIAK, RSJ
通讯作者：
FRACKOWIAK, RSJ