Monkeypox transmission and pathogenesis in prairie dogs.
Monkeypox transmission and pathogenesis in prairie dogs.
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DOI：
10.3201/eid1003.030878
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发表时间：
2004-03
影响因子：
11.8
通讯作者：
Veterinary Monkeypox Virus Working Group
中科院分区：
文献类型：
--
作者：
Guarner J;Johnson BJ;Paddock CD;Shieh WJ;Goldsmith CS;Reynolds MG;Damon IK;Regnery RL;Zaki SR;Veterinary Monkeypox Virus Working Group
2003年5月和6月，美国报告了第一批人猴痘病例。大多数患有这种发热性水泡性皮疹疾病的患者可能是从草原土拨鼠那里感染的。通过聚合酶链反应在两只土拨鼠中证实了猴痘病毒，病理学研究显示坏死性支气管炎、结膜炎和舌溃疡。正痘病毒的免疫组织化学分析表明，丰富的病毒抗原在结膜和舌头的病变的表面上皮细胞，与相邻的巨噬细胞，成纤维细胞和结缔组织中的量较少。肺内病毒抗原在支气管上皮细胞、巨噬细胞和成纤维细胞中丰富。病毒分离和电子显微镜检查表明，在肺和舌活跃的病毒复制。这些发现表明，呼吸道和皮肤粘膜直接接触是猴痘病毒在啮齿动物之间和人类之间传播的潜在重要途径。草原犬提供了深入了解传播，发病机制，新的疫苗和治疗试验，因为它们容易受到严重的猴痘感染。
During May and June 2003, the first cluster of human monkeypox cases in the United States was reported. Most patients with this febrile vesicular rash illness presumably acquired the infection from prairie dogs. Monkeypox virus was demonstrated by using polymerase chain reaction in two prairie dogs in which pathologic studies showed necrotizing bronchopneumonia, conjunctivitis, and tongue ulceration. Immunohistochemical assays for orthopoxviruses demonstrated abundant viral antigens in surface epithelial cells of lesions in conjunctiva and tongue, with less amounts in adjacent macrophages, fibroblasts, and connective tissues. Viral antigens in the lung were abundant in bronchial epithelial cells, macrophages, and fibroblasts. Virus isolation and electron microscopy demonstrated active viral replication in lungs and tongue. These findings indicate that both respiratory and direct mucocutaneous exposures are potentially important routes of transmission of monkeypox virus between rodents and to humans. Prairie dogs offer insights into transmission, pathogenesis, and new vaccine and treatment trials because they are susceptible to severe monkeypox infection.
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影响因子：
9.4
作者：
Meyer, H;Perrichot, M;Formenty, P
通讯作者：
Formenty, P
DOI：
10.1046/j.1439-0450.2002.00532.x
发表时间：
2002-02-01
期刊：
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES AND VETERINARY PUBLIC HEALTH
影响因子：
--
作者：
Meyer, H;Neubauer, H;Pfeffer, M
通讯作者：
Pfeffer, M
影响因子：
3.1
作者：
Meyer, H;Ropp, SL;Esposito, JJ
通讯作者：
Esposito, JJ
影响因子：
6.7
作者：
Heymann, DL;Szczeniowski, M;Esteves, K
通讯作者：
Esteves, K
影响因子：
6
作者：
Guarner, J;Jernigan, JA;Zaki, SR
通讯作者：
Zaki, SR