Activation of human T cells by CD1 and self-lipids.
Activation of human T cells by CD1 and self-lipids.
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DOI：
10.1111/imr.12322
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发表时间：
2015-09
影响因子：
8.7
通讯作者：
de Jong A
中科院分区：
文献类型：
--
作者：
de Jong A
二十多年前，人们发现人类T细胞库包含不识别MHC分子背景下的肽抗原的T细胞，而是对CD 1抗原呈递分子呈递的脂质抗原产生应答。T细胞“看到”与CD 1结合的脂质抗原的能力使这些淋巴细胞能够感知由于感染、炎症或恶性肿瘤而导致的细胞和组织的脂质组成的变化。虽然外来脂质抗原已显示出作为CD 1限制性T细胞的抗原起作用，但许多CD 1限制性T细胞不需要外来抗原来活化，而是可以被CD 1呈递的自身脂质活化。本文综述了该领域的最新进展，包括鉴定作为αβ和γδ T细胞自身抗原的常见哺乳动物脂质，一种新的T细胞活化模式，其中CD 1a本身而不是脂质作为自身抗原，以及调节CD 1自身反应性T细胞活化的各种机制。由于CD 1可以在没有外来抗原的情况下诱导T细胞效应子功能，因此存在多种机制来调节这种自身反应性，并且刺激性CD 1-脂质复合物似乎在空间和时间上受到严格控制。
Over two decades ago, it was discovered that the human T-cell repertoire contains T cells that do not recognize peptide antigens in the context of MHC molecules but instead respond to lipid antigens presented by CD1 antigen-presenting molecules. The ability of T cells to ‘see’ lipid antigens bound to CD1 enables these lymphocytes to sense changes in the lipid composition of cells and tissues as a result of infections, inflammation, or malignancies. Although foreign lipid antigens have been shown to function as antigens for CD1-restricted T cells, many CD1-restricted T cells do not require foreign antigens for activation but instead can be activated by self-lipids presented by CD1. This review highlights recent developments in the field, including the identification of common mammalian lipids that function as autoantigens for αβ and γδ T cells, a novel mode of T-cell activation whereby CD1a itself rather than lipids serves as the autoantigen, and various mechanisms by which the activation of CD1-autoreactive T cells is regulated. As CD1 can induce T-cell effector functions in the absence of foreign antigens, multiple mechanisms are in place to regulate this self-reactivity, and stimulatory CD1-lipid complexes appear to be tightly controlled in space and time.
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影响因子：
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DOI：
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DOI：
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发表时间：
2015-02-09
期刊：
The Journal of experimental medicine
影响因子：
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