B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.
B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.
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作者：
Naive B and T cells exist in discrete zones in lymph nodes. Turley and colleagues demonstrate that a distinct subset of fibroblastic reticular cells reside in B cell zones, where they sustain B cell survival by providing BAFF. The online version of this article (doi:10.1038/ni.2965) contains supplementary material, which is available to authorized users. Fibroblastic reticular cells (FRCs) are known to inhabit T cell–rich areas of lymphoid organs, where they function to facilitate interactions between T cells and dendritic cells. However, in vivo manipulation of FRCs has been limited by a dearth of genetic tools that target this lineage. Here, using a mouse model to conditionally ablate FRCs, we demonstrated their indispensable role in antiviral T cell responses. Unexpectedly, loss of FRCs also attenuated humoral immunity due to impaired B cell viability and follicular organization. Follicle-resident FRCs established a favorable niche for B lymphocytes via production of the cytokine BAFF. Thus, our study indicates that adaptive immunity requires an intact FRC network and identifies a subset of FRCs that control B cell homeostasis and follicle identity. The online version of this article (doi:10.1038/ni.2965) contains supplementary material, which is available to authorized users.
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影响因子：
7.3
作者：
Astarita JL;Acton SE;Turley SJ
通讯作者：
Turley SJ
DOI：
10.1084/jem.192.10.1425
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gretz JE;Norbury CC;Anderson AO;Proudfoot AE;Shaw S
通讯作者：
Shaw S
影响因子：
7.3
作者：
Katakai T
通讯作者：
Katakai T
影响因子：
48
作者：
Buch, T;Heppner, FL;Waisman, A
通讯作者：
Waisman, A
通过淋巴样基质调节T细胞启动。
影响因子：
3.7
作者：
Khan O;Headley M;Gerard A;Wei W;Liu L;Krummel MF
通讯作者：
Krummel MF