Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer.
Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer.
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DOI：
10.3389/fimmu.2012.00200
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发表时间：
2012
影响因子：
7.3
通讯作者：
Katakai T
中科院分区：
文献类型：
--
作者：
Katakai T
次要淋巴器官（slo）的结构由几种非造血基质细胞支持。目前已经确定，两个不同的基质亚群，滤泡树突状细胞和成纤维网状细胞，分别在slo内组织区室的形成中起着至关重要的作用，即滤泡区和T区。虽然胶原中的基质细胞对SLO的发育至关重要，但这些原始细胞与成年期SLO亚群之间的关系仍然知之甚少。此外，基质细胞在抗原通过slo特有的一些组织结构进入隔室中的作用尚不清楚。最近发现的一种基质亚群，边缘网状细胞（MRCs），覆盖了主要位于卵泡外缘的slo边缘，并构建了独特的网状结构。MRCs与抗原运输的特殊内皮或上皮结构密切相关。在发育过程中，标记物表达谱和连续定位的相似性表明，MRCs直接来自于原组织基质细胞。因此，MRCs被认为是slo组织和功能的重要基质成分。
The architecture of secondary lymphoid organs (SLOs) is supported by several non-hematopoietic stromal cells. Currently it is established that two distinct stromal subsets, follicular dendritic cells and fibroblastic reticular cells, play crucial roles in the formation of tissue compartments within SLOs, i.e., the follicle and T zone, respectively. Although stromal cells in the anlagen are essential for SLO development, the relationship between these primordial cells and the subsets in adulthood remains poorly understood. In addition, the roles of stromal cells in the entry of antigens into the compartments through some tissue structures peculiar to SLOs remain unclear. A recently identified stromal subset, marginal reticular cells (MRCs), covers the margin of SLOs that are primarily located in the outer edge of follicles and construct a unique reticulum. MRCs are closely associated with specialized endothelial or epithelial structures for antigen transport. The similarities in marker expression profiles and successive localization during development suggest that MRCs directly descend from organizer stromal cells in the anlagen. Therefore, MRCs are thought to be a crucial stromal component for the organization and function of SLOs.
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DOI：
10.1084/jem.192.10.1425
发表时间：
2000-11-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gretz JE;Norbury CC;Anderson AO;Proudfoot AE;Shaw S
通讯作者：
Shaw S
DOI：
10.4049/jimmunol.1101724
发表时间：
2011-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chyou S;Benahmed F;Chen J;Kumar V;Tian S;Lipp M;Lu TT
通讯作者：
Lu TT
影响因子：
4.4
作者：
Huber, C;Thielen, C;Aguzzi, A
通讯作者：
Aguzzi, A
影响因子：
10.5
作者：
Dougall, WC;Glaccum, M;Schuh, J
通讯作者：
Schuh, J
影响因子：
4.4
作者：
Katakai, T;Hara, T;Shimizu, A
通讯作者：
Shimizu, A