GABAergic circuits control stimulus-instructed receptive field development in the optic tectum.
GABAergic circuits control stimulus-instructed receptive field development in the optic tectum.
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DOI：
10.1038/nn.2612
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发表时间：
2010-09
影响因子：
25
通讯作者：
Akerman, Colin J.
中科院分区：
文献类型：
--
作者：
Richards, Blake A.;Voss, Oliver P.;Akerman, Colin J.
在感觉系统的发育过程中，感受野被环境中的刺激所改变。这被认为依赖于对细胞间尖峰时间相关性敏感的学习算法，但开发电路选择性地利用与感觉输入相关的相关性的方式尚不清楚。我们对非洲爪哇发育中的视顶盖神经元进行了记录，发现重复呈现移动的视觉刺激会引起反映刺激性质的感受野变化，当GABA能传递被阻断时，这种形式的学习就会中断。与棘波计时依赖机制的作用一致，GABA阻断改变了顶盖的棘波计时模式，并增加了细胞之间的相关性，这将影响丘脑内突触的可塑性。这是一个以前未知的GABA能信号在发育中的作用，并突显了调节尖峰活动统计对学习的重要性。
During the development of sensory systems, receptive fields are modified by stimuli in the environment. This is thought to rely on learning algorithms that are sensitive to correlations in spike timing between cells, but the manner in which developing circuits selectively exploit correlations that are related to sensory inputs is unknown. We recorded from neurons in the developing optic tectum of Xenopus laevis and found that repeated presentation of moving visual stimuli induced receptive field changes that reflect the properties of the stimuli and that this form of learning was disrupted when GABAergic transmission was blocked. Consistent with a role for spike timing–dependent mechanisms, GABA blockade altered spike-timing patterns in the tectum and increased correlations between cells that would affect plasticity at intratectal synapses. This is a previously unknown role for GABAergic signals in development and highlights the importance of regulating the statistics of spiking activity for learning.
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