Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity.
Mild intrauterine hypoperfusion reproduces neurodevelopmental disorders observed in prematurity.
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DOI：
10.1038/srep39377
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发表时间：
2016-12-20
影响因子：
4.6
通讯作者：
Tsuji M
中科院分区：
文献类型：
--
作者：
Ohshima M;Coq JO;Otani K;Hattori Y;Ogawa Y;Sato Y;Harada-Shiba M;Ihara M;Tsuji M
严重的宫内缺血对发育中的大脑有害。然而，轻度宫内灌注不足对神经发育的影响尚不清楚。我们在胚胎第17天通过用金属微弹簧圈包裹子宫和卵巢动脉进行动脉狭窄来诱导大鼠轻度子宫内灌注不足。所有幼仔出生时体重均显著降低。观察到灰质和白色区减少，无明显组织损伤。幼仔出现新生儿反射延迟、肌肉无力和自发活动改变。指示脉管系统中炎症和应激的蛋白质水平，即，RANTES、vWF、VEGF和脂联素在胎盘中上调。与轴突和星形胶质细胞发育相关的蛋白质的mRNA水平在胎儿脑中下调。本研究表明，即使是轻度的宫内灌注不足也会改变神经发育，这与早产或宫内生长受限的神经发育障碍儿童的临床体征和症状相似。
Severe intrauterine ischemia is detrimental to the developing brain. The impact of mild intrauterine hypoperfusion on neurological development, however, is still unclear. We induced mild intrauterine hypoperfusion in rats on embryonic day 17 via arterial stenosis with metal microcoils wrapped around the uterine and ovarian arteries. All pups were born with significantly decreased birth weights. Decreased gray and white matter areas were observed without obvious tissue damage. Pups presented delayed newborn reflexes, muscle weakness, and altered spontaneous activity. The levels of proteins indicative of inflammation and stress in the vasculature, i.e., RANTES, vWF, VEGF, and adiponectin, were upregulated in the placenta. The levels of mRNA for proteins associated with axon and astrocyte development were downregulated in fetal brains. The present study demonstrates that even mild intrauterine hypoperfusion can alter neurological development, which mimics the clinical signs and symptoms of children with neurodevelopmental disorders born prematurely or with intrauterine growth restriction.
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