Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.
Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies.
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DOI：
10.1038/ncomms13471
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发表时间：
2016-11-14
影响因子：
16.6
通讯作者：
Saitoe, Minoru
中科院分区：
文献类型：
--
作者：
Hirano, Yukinori;Ihara, Kunio;Masuda, Tomoko;Yamamoto, Takuya;Iwata, Ikuko;Takahashi, Aya;Awata, Hiroko;Nakamura, Naosuke;Takakura, Mai;Suzuki, Yusuke;Horiuchi, Junjiro;Okuno, Hiroyuki;Saitoe, Minoru
越来越多的证据表明，转录调控是维持长期记忆（LTM）所必需的。在这里，我们的特点全球转录和表观遗传的变化，发生在LTM存储在果蝇蘑菇体（MB），结构重要的记忆。虽然LTM的形成需要CREB转录因子及其共激活因子CBP，但随后的早期维持需要CREB和不同的共激活因子CRTC。晚期维持变得不依赖CREB，而是需要转录因子Bx。Bx表达最初依赖于CREB/CRTC活性，但后来变得不依赖于CREB/CRTC。CREB/CRTC早期维持阶段的时间与LTM消退的时间窗相关，我们确定了记忆维持和消退所需的CREB/CRTC靶基因的不同子集。此外，我们发现延长CREB/CRTC依赖的转录延长了LTM消退的时间窗口。我们的研究结果表明，存储的记忆和它的调节移动转录系统中的MB的动态性质。转录调控是维持长期记忆（LTM）所必需的，但其机制细节尚未完全确定。在这里，作者确定了果蝇中LTM维持所需的转录机制和组蛋白修饰剂，并表明LTM维持的转录调控与LTM形成的转录调控不同。
Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requires the CREB transcription factor and its coactivator, CBP, subsequent early maintenance requires CREB and a different coactivator, CRTC. Late maintenance becomes CREB independent and instead requires the transcription factor Bx. Bx expression initially depends on CREB/CRTC activity, but later becomes CREB/CRTC independent. The timing of the CREB/CRTC early maintenance phase correlates with the time window for LTM extinction and we identify different subsets of CREB/CRTC target genes that are required for memory maintenance and extinction. Furthermore, we find that prolonging CREB/CRTC-dependent transcription extends the time window for LTM extinction. Our results demonstrate the dynamic nature of stored memory and its regulation by shifting transcription systems in the MBs. Transcriptional regulation is necessary for maintaining long-term memories (LTM) but the mechanistic details are not completely defined. Here the authors identify transcriptional machinery and histone modifiers required for LTM maintenance in Drosophila and show that transcriptional regulation for LTM maintenance is distinct from that for LTM formation.
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影响因子：
2.7
作者：
Day, Jeremy J;Sweatt, J David
通讯作者：
Sweatt, J David
DOI：
10.1038/nrm3072
发表时间：
2011-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
3.3
作者：
Fischer, JA;Acosta, S;Hook, J
通讯作者：
Hook, J
影响因子：
2.7
作者：
Golub, Yulia;Mauch, Christoph P.;Wotjak, Carsten T.
通讯作者：
Wotjak, Carsten T.