PlnTFDB: an integrative plant transcription factor database.
PlnTFDB: an integrative plant transcription factor database.
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DOI：
10.1186/1471-2105-8-42
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发表时间：
2007-02-07
影响因子：
3
通讯作者：
Mueller-Roeber B
中科院分区：
文献类型：
--
作者：
Riaño-Pachón DM;Ruzicic S;Dreyer I;Mueller-Roeber B
转录因子（Transcription Factor，TF）是一类重要的调控蛋白，在上游信号级联激活或失活时，通过与特定的启动子区（即顺式作用元件）结合来提高或抑制其靶基因的转录速率。因此，转录因子构成了动态转录网络的主控元件。转铁蛋白在几乎所有的生物过程（发育，生长和对环境因素的反应）中发挥着重要作用，并且被认为在物种进化中发挥着非常重要的功能。在植物中，TF已被用于操纵各种类型的代谢、发育和应激反应途径。跨物种的比较和鉴定的调控模块，因此TF被认为是新的植物生物量的合理设计变得越来越重要。然而，到目前为止，还没有一个计算库可以提供对测序的植物基因组的大部分完整的转录因子集的访问。PlnTFDB是一个整合的植物转录因子数据库，它提供了一个网络界面来访问几种植物物种的大量（接近完整）转录因子集，目前包括拟南芥（塔勒水芹）、大叶杨（白杨）、水稻（水稻）、莱茵衣藻和桃牡蛎。它还提供了一个访问点，以物种为中心的转录因子（OstreoTFDB，ChlamyTFDB，ArabTFDB，PoplarTFDB和RiceTFDB）的子数据库表示。信息包括蛋白质序列，编码区，基因组序列，表达序列标签（EST），域架构和科学文献提供了每个家庭。我们已经为五种植物基因组创建了完整的转录因子和其他转录调节因子的列表。它们通过公开提供。将来当其他植物基因组序列可用时，将包括进一步的数据。
Transcription factors (TFs) are key regulatory proteins that enhance or repress the transcriptional rate of their target genes by binding to specific promoter regions (i.e. cis-acting elements) upon activation or de-activation of upstream signaling cascades. TFs thus constitute master control elements of dynamic transcriptional networks. TFs have fundamental roles in almost all biological processes (development, growth and response to environmental factors) and it is assumed that they play immensely important functions in the evolution of species. In plants, TFs have been employed to manipulate various types of metabolic, developmental and stress response pathways. Cross-species comparison and identification of regulatory modules and hence TFs is thought to become increasingly important for the rational design of new plant biomass. Up to now, however, no computational repository is available that provides access to the largely complete sets of transcription factors of sequenced plant genomes. PlnTFDB is an integrative plant transcription factor database that provides a web interface to access large (close to complete) sets of transcription factors of several plant species, currently encompassing Arabidopsis thaliana (thale cress), Populus trichocarpa (poplar), Oryza sativa (rice), Chlamydomonas reinhardtii and Ostreococcus tauri. It also provides an access point to its daughter databases of a species-centered representation of transcription factors (OstreoTFDB, ChlamyTFDB, ArabTFDB, PoplarTFDB and RiceTFDB). Information including protein sequences, coding regions, genomic sequences, expressed sequence tags (ESTs), domain architecture and scientific literature is provided for each family. We have created lists of putatively complete sets of transcription factors and other transcriptional regulators for five plant genomes. They are publicly available through . Further data will be included in the future when the sequences of other plant genomes become available.
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Pfam：氏族、网络工具和服务。
影响因子：
14.9
作者：
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作者：
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64.8
作者：
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通讯作者：
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影响因子：
4.1
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影响因子：
7.4
作者：
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