The GABAB receptor agonist baclofen administered into the median and dorsal raphe nuclei is rewarding as shown by intracranial self-administration and conditioned place preference in rats.
The GABAB receptor agonist baclofen administered into the median and dorsal raphe nuclei is rewarding as shown by intracranial self-administration and conditioned place preference in rats.
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DOI：
10.1007/s00213-009-1757-3
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发表时间：
2010-03
影响因子：
3.4
通讯作者：
Ikemoto, Satoshi
中科院分区：
文献类型：
--
作者：
Shin, Rick;Ikemoto, Satoshi
关键词：
中脑中缝区域长期以来一直与情感过程和疾病有关。越来越多的证据表明，中缝核（MR）和中缝背核（DR）强直性地抑制与奖励相关的过程。刺激中脑中缝核GABAB受体可抑制局部神经元，尤其是血清素能神经元。我们试图确定注射GABAB受体激动剂巴氯芬进入MR或DR是否有回报，使用颅内自我给药和条件位置偏好。大鼠很快学会了杠杆按压以将巴氯芬（0.1-2.5 mM）注入MR，但不包括腹侧被盖区或中央线状核。大鼠与dr内巴氯芬输注相关的杠杆按压增加，但不容易。通过与GABAB受体拮抗剂SCH 50911 （1 mM）或与多巴胺受体拮抗剂SCH 23390 （0.025 mg/kg, i.p）共同给药，巴氯芬自我给药到MR或DR的剂量减少。此外，在dr和mr内注射巴氯芬诱导条件位置偏好；DR内注射更有效。向中脑中缝核注射巴氯芬是有益的。巴氯芬更容易自我注射到核磁共振区而不是核磁共振区，而巴氯芬注射到核磁共振区比注射到核磁共振区更容易诱导条件位置偏好。这些部位可能在奖励方面有不同的参与。这些发现表明含有GABAB受体的MR或DR神经元参与了对奖励过程的强直性抑制控制。
The midbrain raphe regions have long been implicated in affective processes and disorders. There is increasing evidence to suggest that the median (MR) and dorsal raphe nuclei (DR) tonically inhibit reward-related processes. Stimulation of GABAB receptors in the midbrain raphe nuclei is known to inhibit local neurons, especially serotonergic neurons. We sought to determine if injections of the GABAB receptor agonist baclofen into the MR or DR are rewarding, using intracranial self-administration and conditioned place preference. Rats quickly learned to lever press for infusions of baclofen (0.1–2.5 mM) into the MR, but not the ventral tegmental area or central linear nucleus. Rats increased lever pressing associated with intra-DR baclofen infusions, but not readily. Baclofen self-administration into the MR or DR was attenuated by coadministration of the GABAB receptor antagonist SCH 50911 (1 mM) or systemic pretreatment with the dopamine receptor antagonist SCH 23390 (0.025 mg/kg, i.p.). In addition, intra-DR and intra-MR injections of baclofen induced conditioned place preference; injection into DR was more effective. Baclofen injections into the midbrain raphe nuclei are rewarding. Baclofen was more readily self-administered into the MR than into the DR, while baclofen injections into the DR more readily induced conditioned place preference than those into the MR. These sites may be differentially involved in aspects of reward. These findings suggest that MR or DR neurons containing GABAB receptors are involved in tonic inhibitory control over reward processes.
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影响因子：
3
作者：
Ikemoto, S;Sharpe, LG
通讯作者：
Sharpe, LG
影响因子：
6.1
作者：
KLITENICK, MA;WIRTSHAFTER, D
通讯作者：
WIRTSHAFTER, D
影响因子：
4.2
作者：
Judge, SJ;Ingram, CD;Gartside, SE
通讯作者：
Gartside, SE
影响因子：
--
作者：
EMRICH, HM;VONZERSSEN, D;WINDORFER, A
通讯作者：
WINDORFER, A
影响因子：
5
作者：
INNIS, RB;AGHAJANIAN, GK
通讯作者：
AGHAJANIAN, GK