Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer.
Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer.
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DOI：
10.1186/s12943-022-01503-1
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发表时间：
2022-01-26
期刊：
影响因子：
37.3
通讯作者：
Kumar D
中科院分区：
文献类型：
--
作者：
Raj S;Kesari KK;Kumar A;Rathi B;Sharma A;Gupta PK;Jha SK;Jha NK;Slama P;Roychoudhury S;Kumar D
头颈癌是全球第六大常见癌症。这通常与烟酒消费有关。人类乳头瘤病毒(HPV)感染主要发生在咽部，头颈部鳞状细胞癌(HNSCC)可分为HPV阳性和HPV阴性。异常的间充质-上皮转化因子(c-MET)信号转导通路通过刺激HNSCC的增殖、运动、侵袭、形态形成和血管生成，促进HNSCC的进展。在大多数头颈部鳞状细胞癌中都可以发现c-met的上调。C-Met途径作用于多个下游效应分子，包括磷脂酶C-γ(PLCγ)、细胞型Src激酶(c-Src)、磷脂酰肌醇-3-羟基激酶(PI3K)、α-丝氨酸/苏氨酸蛋白激酶(AKT)、丝裂原活化蛋白激酶(MAPK)和无翼相关整合位点(WNT)途径。C-Met还与表皮生长因子受体(EGFR)建立了一条串扰通路，参与了HNSCC的化疗耐药。近年来，c-Met/HGF在HNSCC代谢紊乱、肿瘤微环境和免疫调节等方面的信号传递已初露端倪。针对c-met/肝细胞生长因子(HGF)信号网络的几项临床试验已经建立，以提出针对HNSCC的靶向和有效的治疗策略。本文就c-met/HGF信号转导的分子机制(S)、目前对c-met/HGF信号转导的认识及其对人神经干细胞癌的影响进行综述。
Head and neck cancer is the sixth most common cancer across the globe. This is generally associated with tobacco and alcohol consumption. Cancer in the pharynx majorly arises through human papillomavirus (HPV) infection, thus classifying head and neck squamous cell carcinoma (HNSCC) into HPV-positive and HPV-negative HNSCCs. Aberrant, mesenchymal-epithelial transition factor (c-MET) signal transduction favors HNSCC progression by stimulating proliferation, motility, invasiveness, morphogenesis, and angiogenesis. c-MET upregulation can be found in the majority of head and neck squamous cell carcinomas. c-MET pathway acts on several downstream effectors including phospholipase C gamma (PLCγ), cellular Src kinase (c-Src), phosphotidylinsitol-3-OH kinase (PI3K), alpha serine/threonine-protein kinase (Akt), mitogen-activated protein kinase (MAPK), and wingless-related integration site (Wnt) pathways. c-MET also establishes a crosstalk pathway with epidermal growth factor receptor (EGFR) and contributes towards chemoresistance in HNSCC. In recent years, the signaling communications of c-MET/HGF in metabolic dysregulation, tumor-microenvironment and immune modulation in HNSCC have emerged. Several clinical trials have been established against c-MET/ hepatocyte growth factor (HGF) signaling network to bring up targeted and effective therapeutic strategies against HNSCC. In this review, we discuss the molecular mechanism(s) and current understanding of c-MET/HGF signaling and its effect on HNSCC.
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影响因子：
--
作者：
Cai Y;Dodhia S;Su GH
通讯作者：
Su GH
影响因子：
64.8
作者：
DEAN, M;PARK, M;VANDEWOUDE, GF
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影响因子：
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作者：
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DOI：
10.1007/978-1-4939-6448-2_1
发表时间：
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期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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